How are Nitrogenous Bases attracted to each other?

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banaji727
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How are Nitrogenous Bases attracted to each other?

Post by banaji727 » Wed Sep 23, 2009 8:53 am

I know that in DNA, A goes with T and G goes with C, but how are they attracted to each other in the first place?

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JackBean
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Post by JackBean » Wed Sep 23, 2009 1:41 pm

1) this is Watson-Crick pairing, but actually, they do not have to pair in this manner (especially in RNA)
2) they form hydrogen-bridges, G-C three, A-T two ;) Other pairing is less favorable and leads to irregularities
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

Darwin420
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Post by Darwin420 » Thu Sep 24, 2009 4:37 am

-Hydrogen bonding and also hydrophobic interactions between bases. The nitrogenous bases pair mainly by hydrogen bonding but since DNA is in a high water concentration in its native state the bases also show a hydrophobic tendency and move closer to eachother and away from the solution, which causes you to have a B form DNA strand.

If you put DNA in vitro with a low water concentration, you would witness the bases would stretch further apart. This is due to being in a lower water concentration thus, the bases are "less water fearing" thus the bases are further apart from eachother.

But the major force would be the hydrogen bonding, but it is also good to know the hydrophobic reactions that go on as well.

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