Inhibition of enzyme - will it result in upregulation?

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Jamus
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Inhibition of enzyme - will it result in upregulation?

Post by Jamus » Sat Apr 25, 2009 12:49 pm

Hey all,
I am trying to figure out a mystery here. In an experiment that I've done a few weeks ago, ketoconazole (CYP inhibitor) seems to result in an overall increase in the quantity of the CYP 450 proteins in the liver. I can understand how this works if it is a CYP inducer, but... can an inhibitor have such a profound effect that the cell attempts to compensate for the loss in the ability to metabolise substances that it upregulates the synthesis of the CYP?

I've been googling for the past few hours, but nothing solid has come up :(

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