what's the purpose to crosslink receptors using Abs

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Takara
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what's the purpose to crosslink receptors using Abs

Post by Takara » Tue Feb 17, 2009 2:35 am

In immunology literatures, I often noticed people using some antibodies to crosslink the corresponding receptors. I do not know the exact reason.
1. Why needs crosslinking using Abs? Does crosslinking make dimer or trimer of receptor formation?
2. What the signaling effects after crosslinking? active or block?
3. Which kind of antibodies can be used to crosslink receptors? Is it mentioned in Ab datasheet?
4. Immorbilized antibodies can be used to crosslink? How about soluble antibodies? Thanks a lot in advance :D

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