cAMP as second messenger in GPCR signal transduction

Discussion of all aspects of cellular structure, physiology and communication.

Moderators: Leonid, amiradm, BioTeam

Post Reply
hplc
Garter
Garter
Posts: 9
Joined: Thu Sep 04, 2008 1:10 pm

cAMP as second messenger in GPCR signal transduction

Post by hplc » Sun Feb 15, 2009 12:31 pm

Hello.

I'm currently reading about the signal transduction from G protein-coupled receptors in relation to the cAMP second messenger. But after this chapter, in every example of signal transduction, the book uses cAMP as a second messenger and activator of protein kinase A. They do this for the rest of the book. Not only in the chapter I'm currently reading.

Does this mean that cAMP is the only sencond messenger we have, or is it used only in GPCR signal transduction? Or how does it work?

Thank you.

User avatar
MrMistery
Inland Taipan
Inland Taipan
Posts: 6832
Joined: Thu Mar 03, 2005 10:18 pm
Location: Romania(small and unimportant country)
Contact:

Post by MrMistery » Sun Feb 15, 2009 4:13 pm

cAMP is definitely not the only second messenger we have. other examples include cGMP and Calcium ions.
And no, GPCRs do relay the message solely through cAMP, they can, as I remember, activate phospholipase C and guanynyl cyclase as well.
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter

hplc
Garter
Garter
Posts: 9
Joined: Thu Sep 04, 2008 1:10 pm

Re: cAMP as second messenger in GPCR signal transduction

Post by hplc » Mon Feb 16, 2009 7:09 pm

Thank you very much for your help.

addisongrace22
Garter
Garter
Posts: 2
Joined: Wed Oct 07, 2009 7:09 pm

Re: cAMP as second messenger in GPCR signal transduction

Post by addisongrace22 » Wed Oct 07, 2009 7:31 pm

thanks for such a good in depth explaination of second messengers. :D

Post Reply

Who is online

Users browsing this forum: No registered users and 1 guest