Discussion of all aspects of cellular structure, physiology and communication.
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It suggests that the enzyme is not rigid and that it actually changes its shape slightly to fit the profile of the substrate. The enzyme will mould its self around the substrate as it does this it puts strain on the substrate molecule. The strain distorts a particular bond and lowers the activation energy needed to break the bond. It explains how molecules can affect enzyme activity and how the activation energy is lowered.
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