IgM to IgD transition

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MrMistery
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IgM to IgD transition

Post by MrMistery » Wed May 07, 2008 2:40 pm

What is the molecular mechanism by which IgM to IgD transition occurs in the development of an immature naive B cell into a mature naive B cell?
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blcr11
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Re: IgM to IgD transition

Post by blcr11 » Wed May 07, 2008 3:11 pm

Apparently there are two mechanisms: class-switch recombination and alternative splicing.

http://www.pubmedcentral.nih.gov/articl ... d=16895553

Not sure if this review addresses the developmental aspects of IgD expression, though.

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Post by MrMistery » Wed May 07, 2008 3:28 pm

uhum. Thanks. CSR does not appear in this case in humans, with the exceptions noted there. That is really why I asked, cause I found in a couple of books that there is no switch signal before the delta heavy chain gene region, thus making CSR impossible.
Thus, i have my answer: alternative splicing.
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter

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