genetic disease questions

Genetics as it applies to evolution, molecular biology, and medical aspects.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
hktommy
Garter
Garter
Posts: 1
Joined: Mon Apr 21, 2008 4:43 am

genetic disease questions

Post by hktommy » Mon Apr 21, 2008 6:05 am

Hi all,

First of all, I think I must apologize for posting this topic coz I know this is not a proper topic in this forum and I am a outsider of Biology.

Actually, I am a sufferer of a hereditary disease (Peutz-Jeghers_syndrome, http://en.wikipedia.org/wiki/Peutz-Jeghers_syndrome). I know that there is a chance for me to pass it onto my child but I am still looking for information and advices . . . .

Is the chance exactly 50%?
Is there anyway to reduce the chance?
If it doesn't pass to my child, is that mean it is completely removed from my descendants?
People with this kind of diseases are usually not adviced to have children?

Thank you very much for your time!

User avatar
mith
Inland Taipan
Inland Taipan
Posts: 5345
Joined: Thu Jan 20, 2005 8:14 pm
Location: Nashville, TN
Contact:

Post by mith » Mon Apr 21, 2008 2:26 pm

You should ask a real geneticist/doctor about this.
Living one day at a time;
Enjoying one moment at a time;
Accepting hardships as the pathway to peace;
~Niebuhr

Cat
King Cobra
King Cobra
Posts: 635
Joined: Thu Feb 14, 2008 7:40 pm

Re: genetic disease questions

Post by Cat » Mon Apr 21, 2008 5:48 pm

First, do you know for sure that your Peutz-Jeghers syndrome is caused by STK11/LKB1? That is not the only gene locus responsible (other unknown genes could be involved). You need to be tested to find out. If it’s due to another mutation then nothing is known (neither chances not if it’s dominant or recessive).

“Is the chance exactly 50%?”
Theoretically yes, but in practice it depends on luck. Also, the percentages would be more accurate in large populations, not if you have a couple of kids.

“Is there any way to reduce the chance?”
Not sure, but I do not think so (short of in vitro).

“If it doesn't pass to my child, is that mean it is completely removed from my descendants?”
If it is STK11/LKB1, then yes it will be removed since mutation is dominant.

“People with this kind of diseases are usually not advised to have children?”
You need to discuss this with your doctor like Mith suggested.

Post Reply

Who is online

Users browsing this forum: No registered users and 8 guests