kitasamycin is Belonging to the macrolide antibiotic

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kitasamycin is Belonging to the macrolide antibiotic

Post by hinapharm » Sat Dec 15, 2007 4:23 am

Kitasamycin was developed by Japanese Kitasa Institute in 1960. The antibiotic was produced by Streptomycin kitasatoensis with the active compound of 16 carbon macrolide. The antibiotic has other names such as Selectomycin, leucomycin, ayermicina, sineptin. This antibiotic was approved by Ministry of Agriculture in 2001 as the growth promoter additive in poultry and swine to control and prevent digestive and respiratory diseases.

Chemical and physical properties of Kitasamycin
◇Active components
Kitasamycin is a macrolide antibiotic. There are several active components such as A1, A2, A3, A4, A5, A6, A7, A8, A9, B1, B2, B3, B4. Among these components, B1, B2, B3 and B4 have almost half of that much of activities of A’s and with higher toxicities. A1, B1, B3, B4 are white crystals. A3, A4, A5, A8 and A9 are white pillar shape crystals. A7 is white needle shape crystal. All of the active components are basic, some are soluble in organic solution, almost not soluble in water (less than 0.1%). The melting point is 125 – 137 C.
Kitasamycin is stable in neutral and weak basic condition. Its activity declines when it is the condition of pH more than 5.5.
Pharmacology Characteristic:
Belonging to the macrolide antibiotic, its antibacterial activity is similar to tylosin, erythromycin, spiramycin and oleandomycin. The mode of action is to inhibit the protein synthesis process. Its inhibition spectrum includes Mycoplasmas, Gram-positive bacteria, some Gram-negative bacteria, Leptospira, Rickettsia. It also inhibits most bacteria resistant to penicillin, oxytetracycline, chlortetracycline, erythromycin and chloramphenicol bacteria strains. It is a safe and high efficacy growth-promoting additive for swine and poultry.

Antibiotic spectrum
◇Similar to that of erythromycin,but it is sensitive to Staphylococcus aureus strains that are resistant to erythromycin.
◇Sensitive to bacteria strains that are resistant to penicillin. There are reports that 72%penilicin resistant Staphylococcus.
◇Sensitive to Mycoplasma gallisepticum , Mycoplasma granularum , swine mycoplasa、Siprochaeta ichterobaemorrhagiae and Richettsias.
◇Sensitive to Streptococcus suis, Corynebacterium pyogenes, Streptococcus pneumoniae, Streptococcus pyogenes, Corynebacterium diphtheria, Clostridium perfrigens, Haemophilusparagellinarum, Actinobacillus pleuropneumonia , Campybacter coli.

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