Virus DNA/RNA Questions

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GDU12
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Virus DNA/RNA Questions

Post by GDU12 » Tue Jul 24, 2007 12:51 am

I have a few questions. Do viruses work without their genetic material? I mean can they still infect cells without genetic material? Does the virus or genetic material get damaged or destroyed if a poison is inserted? If you can answer these, then thanks.

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mith
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Post by mith » Tue Jul 24, 2007 2:34 am

poison?
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ping
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Post by ping » Sat Jul 28, 2007 6:45 am

To prevent virus from replication you need protease inhibitor in the cases in which the virus RNA encodes polyprotein which is then cleaved. DNA viruses uses the host cell enzymes to replicate ( and RT) and this is not possible for them.

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Re: Virus DNA/RNA Questions

Post by sdekivit » Sat Jul 28, 2007 9:34 pm

GDU12 wrote:I have a few questions. Do viruses work without their genetic material? I mean can they still infect cells without genetic material? Does the virus or genetic material get damaged or destroyed if a poison is inserted? If you can answer these, then thanks.


in order to affect a cell, the genome of a virus is not required. That depends on the permissiveness en capacity of binding of the virus to it's target cell.

--> the genome is required for a succesfull reproductive cycle of the virus in order to spread.

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Post by sdekivit » Sat Jul 28, 2007 9:36 pm

ping wrote:To prevent virus from replication you need protease inhibitor in the cases in which the virus RNA encodes polyprotein which is then cleaved. DNA viruses uses the host cell enzymes to replicate ( and RT) and this is not possible for them.


if you mean RT = reverse transcriptase, then you're not talking about DNA viruses

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mith
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Post by mith » Sun Jul 29, 2007 3:00 am

Nice to see the virology threads getting answers sdekivit :)
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ping
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Post by ping » Sun Jul 29, 2007 6:39 am

sdekivit wrote:
ping wrote:

if you mean RT = reverse transcriptase, then you're not talking about DNA viruses


I mean dsDNA viruses like Caulimoviruses!!! :evil:
They replicate through RNA intermediates.

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Post by microworld » Sun Aug 19, 2007 9:42 am

The viruses can work without DNA/RNA,such as prion viruses.it can depend the host DNA to finish its replication etc.The typical example is BSE(Bovine Spongiform Encephalopathy)

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Post by canalon » Sun Aug 19, 2007 11:57 pm

Prion are not viruses....
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Post by MrMistery » Mon Aug 20, 2007 10:59 am

I guess it would depend on what kind of poison you are using. The term poison is very vague. For example, the drug oseltamivir phosphate blocks the viral neuroaminidase of the influenza virus, making it unable to enter a host cell.

Most poisons however, are directed at a virus' replication cycle, after it has entered the cell. A nice example is the cocktail treatment of HIV. More drugs are used so that the replication is slowed down in every stage.

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