Theoretical biologists developing a protein folding theory?

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Punita
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Theoretical biologists developing a protein folding theory?

Post by Punita » Mon Jul 16, 2007 6:51 pm

Hi, I wondered if anybody knew whether there are any purely theoretical biologists working on developing a theory of protein folding? Any names would be great! Thanks!

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victor
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Post by victor » Tue Jul 17, 2007 4:14 am

the folding of protein happens in 3 ways, (1) it folds by itself, (2) helped by proteins named chaperones, and (3) helped by a large dome-like protein chaperonins.

for the no.1, it can fold to a proper structure sometimes because of series of actions happened after translation, called post-translational modification, like amino-acid modification. But the major factor that affects the proper folding is that the sequence of each amino-acid in the protein itself :)
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Post by blcr11 » Tue Jul 17, 2007 11:31 am

There should be lots of labs doing this kind of theoretical work--Ken Dill's lab comes to mind (at one of the California universities--I forget which off-hand). Go to PubMed and search for theory protein folding or something similar, then open the reviews tab. You should get lots of possibilities. Open the citation and there should also be at least one contact e-mail or address.

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mith
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Post by mith » Tue Jul 17, 2007 4:31 pm

Probably UCSF, they have some biomedical stuff going on there
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Punita
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Post by Punita » Wed Jul 18, 2007 10:58 am

Thanks guys, that was really useful! Thanks again!

spopov
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hi!

Post by spopov » Thu Jul 26, 2007 7:31 am

You can use algoritm of Mekler L.B. for protein folding preduction. Some deteil is not puplished but in general all clear.

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