molecular weight of Methyl-?-cyclodextrin

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zky
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molecular weight of Methyl-?-cyclodextrin

Post by zky » Mon Jun 04, 2007 9:10 pm

Does anyone know the molecular weight of Methyl-beta-cyclodextrin used for preparing molar solutions? Its data sheet shows that "When calculating molar (e.g., :M, mM, etc.) solutions, the molecular weight of
the cyclodextrin component of the complex is typically disregarded and the solution is prepared considering the amount of the hormone in the preparation and its respective molecular weight (printed in the alphabetical listings of the Sigma catalog)". But I can not find it. Does anyone know any information about it?

Thank you

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canalon
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Post by canalon » Mon Jun 04, 2007 9:32 pm

FW: Approx 1320

See last page of this pdf from Sigma:
http://www.sigmaaldrich.com/sigma/gener ... 555inf.pdf

The second page explains why they do not really care about MW (or formula weight). And I guess that the approximative FW comes from the fact that all subunits are not subsituted, so you can only get an average FW.
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zky
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Post by zky » Mon Jun 04, 2007 11:08 pm

Thank you, canalon. In the beginning, I used the molecular weight of 1320 to prepare MbCD stock and add to cells. However, cells are killed at even 5 mM while some papers showed MbCD did not kill cells at 10mM. That is why I asked the question.

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