## Need help to understand this harvey weinburg problem!!

**Moderators:** honeev, Leonid, amiradm, BioTeam

### Need help to understand this harvey weinburg problem!!

A very large population of lab mice contains 35% white mice. White coloring is caused by the double recessive genotype "aa". Calculate allelic and genotypic frequencies for this population.

a.Homozygous dom genotype:

b.Homezygous recces genotype:

c.Heterozygous genotype:

d.Dominant allele frequency:

e.Recessive allele frequency:

Is there an easy way to calculate this problem? I have tried and am not sure if I am correct.....this is very confusing!!!

Please help!!

Here is my calculation:

aa~ .59 (q2)

A ~ 1.0 (p)

AA~ .17 (p2)

Aa~.48 (2pq)

a.Homozygous dom genotype:

b.Homezygous recces genotype:

c.Heterozygous genotype:

d.Dominant allele frequency:

e.Recessive allele frequency:

Is there an easy way to calculate this problem? I have tried and am not sure if I am correct.....this is very confusing!!!

Please help!!

Here is my calculation:

aa~ .59 (q2)

A ~ 1.0 (p)

AA~ .17 (p2)

Aa~.48 (2pq)

Pr[aa]=0.35 (given)

Pr[a]=q=sqrt(.35)=0.59

Pr[A]=p=1-q=1-0.59=0.41

Pr[AA]=p2=(0.41)(0.41)=0.17

Pr[Aa]=2pq=2(.59)(.41)=0.48

Check p2 + 2pq + q2 = 1 = 0.35 + 0.48 + 0.17

Frequency of:

Homozygous dominant genotype (AA): p2=0.17

Homozygous recessive genotype (aa): q2=0.35

Heterozygous genotype (Aa): 2pq=0.48

Dominant allele (A): p=0.41

Recessive allele (a): q=0.59

I think you were OK except for confusing Pr[aa] with Pr[a].

### Thank you for clearing that up!!

Thank you so much! I see where I made the mistake.

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