URGENT I Need Help!!! Re: leukocytes

Human Anatomy, Physiology, and Medicine. Anything human!

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
dogsrus
Garter
Garter
Posts: 3
Joined: Thu Mar 29, 2007 2:59 pm

URGENT I Need Help!!! Re: leukocytes

Post by dogsrus » Fri Mar 30, 2007 1:03 am

I am in an A&P class and it has been 10 yrs since I have taken the Biology. In the refresher portion of this class I was given a question to answer and not sure if what I am finding is what I really need to look for.

Q: What type of transport would be used by leukocytes when they secrete toxic substances and enzymes on to the surface of parasitic worms in humans?

User avatar
Dr.Stein
King Cobra
King Cobra
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia
Contact:

Post by Dr.Stein » Fri Mar 30, 2007 2:13 am

Large parasites, such as worms, cannot be ingested by phagocytes; however, when the worm is coated with antibody, especially IgE, eosinophils can attack it through their binding to the high-affinity Fc-epsilon-RI. Similar attacks can be mounted by other Fc receptor-bearing cells on various large targets. These cells will release toxic contents of their granules directly onto the target, a process known as exocytosis.

Example:

Image
Eosinophils attacking a schistosome larva.
Image

Darby
Viper
Viper
Posts: 1278
Joined: Thu Mar 02, 2006 5:29 pm
Location: New York, USA

Post by Darby » Fri Mar 30, 2007 2:42 am

Definitely exocytosis - are you studying golgi function?

dogsrus
Garter
Garter
Posts: 3
Joined: Thu Mar 29, 2007 2:59 pm

Post by dogsrus » Fri Mar 30, 2007 3:54 am

No, I am not studing anything specific, the teacher has about 28 questions for General Biology review and has assigned people to each question. Unfortunately, like I said before it has been 10 yrs since I have even looked at anything relating to biology. Is eosinophils or exocytosis the transport system or is it the toxin that is released? I read that Hemolysin which is produced by E-coli has a cytotoxic affect on leukocytes.

User avatar
Dr.Stein
King Cobra
King Cobra
Posts: 3501
Joined: Thu Jul 07, 2005 7:58 am
Location: 55284 Yogyakarta, Indonesia
Contact:

Post by Dr.Stein » Fri Mar 30, 2007 6:16 am

Your words made me confused :roll: Or you don't understand the terms here :?

Eosinophils releases toxin, the mechanism of this toxin releasing is called exocytosis.
Image

User avatar
Revenged
Coral
Coral
Posts: 118
Joined: Sat Oct 07, 2006 10:27 pm

Post by Revenged » Fri Mar 30, 2007 10:25 am

eosinophil is the name of the type of white blood cell that targets worms...

the antibody produced is IgE... IgE binds to the worm...

(where does the IgE come from - i'm not sure...)

the white blood cell can recognise the IgE on the worm and then it can releases 'toxin'...

exocytosis is just a way that the toxin moves out of the cell... and this is what the question is asking about...

http://academic.brooklyn.cuny.edu/biolo ... /exocy.htm

NB. E-coli is a bacteria... It is not relavent to your question about exocytosis/destroying worms...

Hope that helps...

dogsrus
Garter
Garter
Posts: 3
Joined: Thu Mar 29, 2007 2:59 pm

Post by dogsrus » Sat Mar 31, 2007 2:41 am

thank you all for your help, i have a liitle better understanding. :)

Post Reply

Who is online

Users browsing this forum: No registered users and 12 guests