Enzyme actions

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helpneeded
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Enzyme actions

Post by helpneeded » Tue Mar 20, 2007 1:43 am

This is really embarassing :oops: but I dont know what a 'lock and key model' is (when refering to enzymes). Can anyone tell me?
thanks!
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mith
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Post by mith » Tue Mar 20, 2007 10:57 pm

substrate fits into an enzyme's active site like a key into a lock. Both substances are considered rigid.
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Post by Darby » Wed Mar 21, 2007 12:28 am

It's a huge oversimplification, though - much of the time the interaction of the substrate and enzymes changes the shape of one or both. That's where the enzyme's action often comes from.

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Post by victor » Wed Mar 21, 2007 8:48 am

yep, there'll be proximity & orientation effect, acid-base catalysis, covalent catalysis, ionic interaction and enviromental influence effect.....
not as easy as you put the key into the lock....:wink:
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Post by Dustfinger » Wed Mar 21, 2007 8:30 pm

But it's just amodel, and models never do really describe reality.
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Post by mith » Wed Mar 21, 2007 10:23 pm

There's also electrical and van de waals forces involved too, the lock and key model ignores all this.
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