substrate-level phosphorolation

Discussion of all aspects of cellular structure, physiology and communication.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
User avatar
Mr Joe
Garter
Garter
Posts: 20
Joined: Thu Nov 16, 2006 9:39 pm
Location: America

substrate-level phosphorolation

Post by Mr Joe » Sun Mar 11, 2007 2:59 am

substrate-level phosphorolation, what does it in-tale. im confused on the process involved in this, i have a basic idea of whats involved but not completely ............any info is appreciated

User avatar
Revenged
Coral
Coral
Posts: 118
Joined: Sat Oct 07, 2006 10:27 pm

Post by Revenged » Sun Mar 11, 2007 11:31 am

Two receptors use phosphorylation G-protein receptors or tyrosine kinase receptors...

G-protein receptors (e.g. adrenoreceptors)

- Substance binds to adrenorecetptor
- Causes GTP to become GDP
- Causes formation of a secondary messanger, which causes activation / deactivation of a protein kinase (enzyme that phosphorylates protein)
- Enzyme causes a responce

Tyrosine kinase receptor (e.g. insulin receptor)

- Insulin binds to alpha chain of receptor
- Causes phosphorylation of tyrosine in beta chain of receptor
- Causes phosphorylation of intracellular protein

Darby
Viper
Viper
Posts: 1278
Joined: Thu Mar 02, 2006 5:29 pm
Location: New York, USA

Post by Darby » Tue Mar 13, 2007 2:34 am

Also more generally, transferring a phosphate group from ATP often serves to destabilize the substrate, greatly increasing the chances that it will react in particular ways.

User avatar
MrMistery
Inland Taipan
Inland Taipan
Posts: 6832
Joined: Thu Mar 03, 2005 10:18 pm
Location: Romania(small and unimportant country)
Contact:

Post by MrMistery » Sat Mar 17, 2007 3:38 pm

substrate-level phosphorylation also can produce ATP during glycolysis and Krebs cycle(although the most ATP does come from oxidative phosphorylation).
Basically any reaction in which a phosphate group is transferred from one compound to another is substrate-level phosphorylation
"As a biologist, I firmly believe that when you're dead, you're dead. Except for what you live behind in history. That's the only afterlife" - J. Craig Venter

deniqua
Garter
Garter
Posts: 10
Joined: Mon Apr 23, 2007 12:52 am

Post by deniqua » Mon Apr 23, 2007 12:56 am

MrMistery wrote:substrate-level phosphorylation also can produce ATP during glycolysis and Krebs cycle(although the most ATP does come from oxidative phosphorylation).
Basically any reaction in which a phosphate group is transferred from one compound to another is substrate-level phosphorylation

Post Reply

Who is online

Users browsing this forum: No registered users and 10 guests