protein binding, laymen definition please
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protein binding, laymen definition please
I am in pharmacology at a community college. I had other science courses, but am a little hazy on this subject. My study guide states....explain how the effectiveness of a drug is based on distribution. Then it lists 3 different types which are protein binding, distr. to CNS (blood-brain barrier), and mother to fetus. My book does not really give a simple explanation of these processes that I can understand. I thought my comprehension was sufficient until I opened up this book. I did get a 3.5 in Eng 111. Can someone help in this area? I will probably be frequenting this web site several more times as I have nursing school after pharm.
Thanks
Thanks
So what protein binding is is the proportion of the drug that is bound to protein in plasma (most of which is albumin). The protein-bound fraction is inactive and will not be excreted and because of this reason the efficacy and half-life of a drug may vary with its protein binding. Other drugs may also affect another drugs protein binding by displacing it from albumin thereby acutely enhancing a drug's effect due to higher plasma levels (well-known drug interaction most often seen on pharmacology tests!). Protein binding influences the volume of distribution of a drug.
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