Hydrochloric acid (HCL) in the stomach..

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TwinkleK
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Hydrochloric acid (HCL) in the stomach..

Post by TwinkleK » Fri Feb 10, 2012 12:58 pm

Cells in the wall of the mamalian stomach secrete HCL at a concentration of 0.1M.

The secreted -protons, which are derived from the intracellular hydration of CO2 by carbonic anhydrase, are pumped out by an (H+ k+) ATPase antiport transporter is also required to complete the overall transport system.


a) Calculate the pH of the secreted HCL. How does this compare to the cystolic pH of 7.4?

b) Write a reaction catalysed by the carbonic anhydrase enzyme.

c) Draw a diagram to show how the action of both transport proteins results in the secretion of HCL.

d) Explain how a proton pump inhibitor might be effective in the treatment of a stomach ulcer.

Can someone please point me in the right direction? Or just help me out with the first two questions..please?

Thank you:)
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TwinkleK
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Post by TwinkleK » Fri Feb 10, 2012 1:48 pm

Erm, is the answer for question b?

The reaction catalyzed by carbonic anhydrase is:

CO2 + H2O -----(Carbonic anhydrase)-----> HC0-3 + H+
(in tissues - high CO2 concentration)

I'm not sure though..
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JackBean
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Post by JackBean » Fri Feb 10, 2012 1:51 pm

http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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Re: Hydrochloric acid (HCL) in the stomach..

Post by TwinkleK » Fri Feb 10, 2012 3:48 pm

Thanks..

a) Is this like a standard equation? Where do I put my equations in??

b) Sorry, but I am not getting this at all..
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JackBean
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Post by JackBean » Fri Feb 10, 2012 5:42 pm

a) what equations do you want put into where?

b) you got link, where you can search for enzymes. Look for anhydrase and first link is the one you're looking for. There will you find the equation.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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Re: Hydrochloric acid (HCL) in the stomach..

Post by TwinkleK » Sat Feb 11, 2012 3:14 pm

a) how do I use the formula "pH = log10 [H+]"

I can't do this because I don't have the [H+] and I can't rearrange it to find to: "[H+] = log10 pH"


Becuase I don't have the pH, ony the information as given in the question....
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canalon
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Post by canalon » Sat Feb 11, 2012 6:00 pm

Yes you have all the information, and you are right you can say that [H+]= - log10 pH because the invert relation to a log is not another log. But then your problem is that you can't do math.
The thing is [H+]= 10^(- pH)
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any proof. (Ashley Montague)

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JackBean
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Post by JackBean » Sat Feb 11, 2012 8:06 pm

where does the H+ come from?
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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Re: Hydrochloric acid (HCL) in the stomach..

Post by TwinkleK » Sat Feb 11, 2012 9:39 pm

Well it's the amoount of hydrogen ions isn't it?
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JackBean
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Post by JackBean » Sun Feb 12, 2012 4:48 pm

no, it's concentration. And that's not what I asked for.
http://www.biolib.cz/en/main/

Cis or trans? That's what matters.

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