Origins of Molecular Chaperones ?

Discussion of all aspects of biological molecules, biochemical processes and laboratory procedures in the field.

Moderators: honeev, Leonid, amiradm, BioTeam

Post Reply
Posts: 35
Joined: Wed Dec 22, 2004 5:03 am

Origins of Molecular Chaperones ?

Post by cloudnine » Sat Jan 01, 2005 5:00 am

Hello everyone, please tell me what may be the answer.

In protein synthesis, the functional protein is the one with the correct folding pattern.
This is aided by the special proteins called chaperones.
In this case, when these proteins were first synthesized, what is the assisting factors to fold them to function as chaperones?
Is that concerned with maternal genes, or the genes products from mother?
if not, what is meant by correct folding of proteins?
Or what is the command for the first folding of the first protein of life?


User avatar
Inland Taipan
Inland Taipan
Posts: 347
Joined: Thu Jan 27, 2005 7:39 pm
Location: Vancouver, Canada

Post by thank.darwin » Fri Feb 11, 2005 2:15 pm

I can't help you with all of your questions but I will give you some information about the folding of a protein... Proteins fold because bonds, such as a hydrogen bond, form between the proteins. It all has to do with the remainder group of the protein.
- Hoped that helped?
No amount of experimentation can ever prove me right; a single experiment can prove me wrong.
-Albert Einstein

Death Adder
Death Adder
Posts: 82
Joined: Wed Jan 26, 2005 12:32 pm
Location: UK

Post by DevGrp » Fri Feb 11, 2005 3:26 pm

many proteins will fold themselves naturally without chaperones.. Gently denature them in a tube, remove the denaturing chemical conditions and they will fold back the way they were.
It is also todo with them finding the best / most stable favoured molecular configuration.

My understanding is that chaperones help protein fold into less favoured configurations which they would not normally fold into without the chaperone.

So the chaperone can probably fold itself and without the chaperone the chaperoned protein would find some other configuration which may well be either inactive / unstable / less active.

hope this helps

Death Adder
Death Adder
Posts: 70
Joined: Mon Feb 07, 2005 10:54 am

Post by RobJim » Sat Feb 19, 2005 4:40 am

Are you asking this question from an evolutionary perspective? This seems like the kind of question proponents of 'irreduceable complexity' might ask.
Rob the Chemicool Mod
Wikipedia and Google are your friends!
Visit the Chemicool forums for all your chemistry needs:

Post Reply

Who is online

Users browsing this forum: No registered users and 11 guests