Inactivating signal transduction pathway?

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comfy_numb
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Inactivating signal transduction pathway?

Post by comfy_numb » Sat Dec 10, 2005 7:20 pm

I just got bogged down with the question..

what are three DISTINCT mechanisms to inactivate an activated signal transduction pathway...examples of each would be helpful.

appreciate your inputs.

comfy_numb
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Post by comfy_numb » Sun Dec 11, 2005 12:28 am

No Ideas?

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Post by Jumpshooter » Thu Dec 15, 2005 4:06 pm

If you want to inactivate the signal transduction pathway in-vivo, you can introduce mutations in the receptor protein that cause it to have a much lower Ka (binding efficiency) to the hormone. Or you can modify the cell membrane with adducts to render the membrane proteins unable to bind the hormone. Also, since Calcium Ca+2 is key to signal transduction, you can add chemical such as EDTA to chelate the Ca+2 ions from the milleux and thereby greatly diminish the liklihood of signal transduction.
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sdekivit
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Re: Inactivating signal transduction pathway?

Post by sdekivit » Thu Dec 15, 2005 5:51 pm

comfy_numb wrote:I just got bogged down with the question..

what are three DISTINCT mechanisms to inactivate an activated signal transduction pathway...examples of each would be helpful.

appreciate your inputs.


inactivivation of a signal:

receptor downregulation / receptor sequestration / receptor inactivation / inactivating phosphorylation/dephosphorylation / production inhibitor proteins / pumping second messenger out of the cell and so on .....

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