Hardy Weinberg Question

Genetics as it applies to evolution, molecular biology, and medical aspects.

ScottP
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Hardy Weinberg Question

Use the Hardy-Weinberg model to calculate the genotype frequencies FGA 20,20, FGA 20,21, and FGA 21,21.

Database size = 1204 alleles
Number of 20 alleles = 172
Number of 21 alleles = 225

Cant seem to get my head around it , any help would be much appreciated
Last edited by ScottP on Fri Aug 25, 2006 10:02 pm, edited 1 time in total.

sdekivit
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is this trait in Hardy-Weinberg equilibrium

even so (i'm not sure about this --> give some explanation what you mean with 'database size': alleles or individuals), you can directly calculate the alelle frequencies p and q from these data, because you know the total of the two alleles in the population.

Then use p^2, 2pq en q^2 to calculate the genotype frequencies.

I think this question is rather misleading, since p + q is not 1, so i doubt whether Hardy-Weinberg can be apllied here.

ScottP
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sdekivit wrote:I think this question is rather misleading, since p + q is not 1, so i doubt whether Hardy-Weinberg can be apllied here.

Thats why it confused me so much

Oops missed out a word for the database size it's 1204 alleles

It's word for word from the exam paper

sdekivit
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since the question says you need to use Hardy-Weinberg, you should use it.

The the allele frequencies would be 172/1204 and 225/1204. Than simply calculate p^2, 2pq and q^2, since p and q are already known.

dipjyoti
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The Hardy-Weinberg model, named after the two scientists that derived it in the early part of this century, describes and predicts genotype and allele frequencies in a non-evolving population. The model has five basic assumptions: 1) the population is large (i.e., there is no genetic drift); 2) there is no gene flow between populations, from migration or transfer of gametes; 3) mutations are negligible; 4) individuals are mating randomly; and 5) natural selection is not operating on the population. Given these assumptions, a population's genotype and allele frequencies will remain unchanged over successive generations, and the population is said to be in Hardy-Weinberg equilibrium. The Hardy-Weinberg model can also be applied to the genotype frequency of a single gene.

For the Hardy-Weinberg model to calculate the genotype frequencies plse log on to
http://www19.homepage.villanova.edu/ali ... inberg.htm
http://www.clinchem.org/cgi/content/full/45/2/178

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