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- Posts: 1
- Joined: Mon Jul 15, 2013 6:59 am
Does X chromosome inactivation only occur in female?? Is that any possibality that happens on male??
- Posts: 7
- Joined: Mon Mar 12, 2012 1:38 pm
X chromosome inactivation happens only in the presence of multiple X chromosomes. Male cells do contain only one X chromosome and do therefore not have X chromosome inactivation. X chromosome inactivation is happening through transcriptional repression of the X chromosome. The X chromosome of male germ cells is in a condensed chromatin state and is transcriptionally repressed during early spermatogenesis but to my knowledge this is not considered as "X chromosome inactivation".
In mammals, X chromosome inactivation is random and can happen on the paternal or on the maternal X chromosome.
hope it helps!