Search found 7 matches

by Hodag
Sat Dec 05, 2015 8:12 pm
Forum: General Discussion
Topic: Calcium vs magnesium binding
Replies: 0
Views: 1629

Calcium vs magnesium binding

Trisodium citrate is commonly used as an anticoagulant and works by binding divalent cations. When free calcium falls below about 225 nmols, coagulation cannot proceed. Citrate also binds magnesium, and I have found plenty of reference that state that when performing regional anticoagulation with ci...
by Hodag
Sat Dec 05, 2015 7:52 pm
Forum: General Discussion
Topic: Coagulation, is factor IX a required part of external path?
Replies: 1
Views: 1595

The answer is yes, Factor IX is required. Let me see if I can explain it better than the book did. There are two ways to activate X to Xa, after which all the steps are the same, hence the name "Common Cascade". The contact activation cascade needs four components to activate Factor X. Fac...
by Hodag
Wed May 12, 2010 4:57 pm
Forum: Human Biology
Topic: Anal Bleeding. Pleas help.
Replies: 11
Views: 15117

Re: Anal Bleeding. Pleas help.

It could be a side effect of your medication, but really, you should be having this chat with your physician and not here. If this is a known side effect of the drug, the physician can tell that by looking at the label for the drug (each prescription medication documents known side effects and sugge...
by Hodag
Sun Jan 03, 2010 2:01 pm
Forum: Human Biology
Topic: Diabetes
Replies: 2
Views: 2451

When food is digested, the sugars wind up in the blood stream. Insulin is a protein that can bind to the glucose molecules and to surface receptors on cells. When blood sugar spikes due to eating a meal or drinking something sweet, the pancreas produces insulin which then binds all the glucose and s...
by Hodag
Sun Jan 03, 2010 12:26 am
Forum: Molecular Biology
Topic: Question about the coagulation cascade
Replies: 0
Views: 2222

Question about the coagulation cascade

I have been looking at a number of sources regarding the contact activation form of the coagulation cascade, and I have seen conflicting information. I am hoping somebody that knows this area well can answer this. In human blood coagulation Factor XII is converted to XIIa in a calcium-independent pr...
by Hodag
Wed Dec 16, 2009 2:37 am
Forum: Cell Biology
Topic: Cadherins
Replies: 2
Views: 3875

Re: Cadherins

Andrei, Thanks for the reply, it is mostly good news. Now I just need to find the concentrations, but PubMed has not been my friend on this one. Normally I live and die by Reference Manager searches but so far nothing helpful. I will have look at the link you provided; perhaps I can go from there. I...
by Hodag
Tue Dec 15, 2009 10:34 pm
Forum: Cell Biology
Topic: Cadherins
Replies: 2
Views: 3875

Cadherins

The action of cadherins are, by their nature, calcium-dependent. I have read a lot of articles, but none of them seem to indicate whether the Ca2+ required is intracellular, extracelluar, or a bit of both (I am guessing both). My question revolves around what happens if you chelate extracellular cal...