- Update on the Neurobiology of Alcohol Withdrawal Seizures

Bayard MJ, Hill KR, Woodside J Jr. Alcohol withdrawal syndrome. Am Fam Physician. 2004;69:1443–1450.
Crews FT, Morrow AL, Criswell H, Breese G. Effects of ethanol on ion channels. Int Rev Neurobiol. 1996;39:283–367.
Deitrich, RA.; Erwin, VG. Pharmacological Effects of Ethanol on the Nervous System. Boca Raton, FL: CRC Press; 1996.
Nevo I, Hamon M. Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem Int. 1995;26:305–336. discussion 337–342.
Hillbom M, Pieninkeroinen I, Leone M. Seizures in alcohol-dependent patients. CNS Drugs. 2003;17:1013–1030.
Kosten TR, O'Connor PG. Management of drug and alcohol withdrawal. N Engl J Med. 2003;348:1786–1795.
Freedland ES, McMicken DB. Alcohol-related seizures, Part I: pathology, differential diagnostic, and evaluation. J Emerg Med. 1993;11:463–473.
Mattson, RH. Seizures associated with alcohol use and alcohol withdrawal. In: Feldman B. , editor. Epilepsy:Diagnosis and Management. Boston: Little Brown; 1983. pp. 325–332.
N'Gouemo, P.; Rogawski, MA. Alcohol withdrawal seizures. In: Pitkänen A, Schwartzkroin PA, Moshé SL. , editors. Models of Seizures and Epilepsy. Amsterdam: Elsevier; 2006.
Hunter BE, Boast CA, Walker DW, Zornetzer SF. Alcohol withdrawal syndrome in rats: Neural and behavioral correlates. Pharmacol Biochem Behav. 1973;1:161–177.
Maxson SC, Sze PY. Electroencephalographic correlates of audiogeneic seizures during ethanol withdrawal in mice. Psychopharmacology. 1976;47:17–20.
Sand T, Brathen G, Michler R, Brodtkorb E, Helde G, Bovim G. Clinical utility of EEG in alcohol-related seizures. Acta Neurol Scand. 2002;105:18–24.
Touchon J, Besset A, Baldy-Moulinier M, Billiard M, Uziel A, Passouant P. Electrophysiological aspect of alcoholic epilepsy. Rev Electroencephalogr Neurophysiol. 1981;14:133–137.
Faingold CL, Riaz A. Ethanol withdrawal induces increased firing in inferior colliculus neurons associated with audiogenic seizure susceptibility. Exp Neurol. 1995;132:91–98.
Chakravarty DN, Faingold CL. Comparison of neuronal response patterns in the external and central nuclei of inferior colliculus during ethanol administration and ethanol withdrawal. Brain Res. 1998;783:102–108.
Yang L, Long C, Faingold CL. Neurons in the deep layers of superior colliculus are a requisite component of the neuronal network for seizures during ethanol withdrawal. Brain Res. 2001;920:134–141.
Yang L, Long C, Faingold CL. Neurons in the periaqueductal gray are critically involved in the neuronal network for audiogenic seizures during ethanol withdrawal. Neuropharmacology. 2003;44:275–281.
Faingold CL. Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action. Prog Neurobiol. 2004;72:55–85.
Touchon J, Rondouin G, DeLustrac C, Billiard M, Baldy-Moulinier M, Cadilhac M. Brainstem auditory evoked potential in “alcoholic epilepsy.” Rev Electroencephalogr Neurophysiol. 1984;14:133–137.
Neiman J, Noldy NE, El-Nesr B, McDonough M, Carlen PL. Late auditory evoked potentials in alcoholics: identifying those with a history of epileptic seizures during withdrawal. Ann N Y Acad Sci. 1991;620:73–81.
Hughes JR, Fino JJ. A review of generators of the brainstem auditory evoked potentials: contribution of an experimental study. J Clin Neurophysiol. 1985;2:355–381.
Goldstein DB, Chin JH. Interaction of ethanol with biological membranes. Fed Proc. 1981;34:2073–2076.
Franks NP, Lieb WR. Is membrane expansion relevant to anaesthesia? Nature. 1981;292:248–251.
Lovinger DM, White G, Weight FF. Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science. 1989;243:1721–1724.
Lovinger DM, White G, Weight FF. NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J Neurosci. 1990;10:1372–1379.
Carta M, Ariwodola OJ, Weiner JL, Valenzuela CF. Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons. Proc Natl Acad Sci U S A. 2003;100:6813–6818.
Lovinger DM, White G. Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons. Mol Pharmacol. 1991;40:263–270.
Davies M. The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. J Psychiatry Neurosci. 2003;28:263–274.
Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL. Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors. Nature. 1997;389:385–389.
Kobayashi T, Ikeda K, Kojima H, Niki H, Yano R, Yoshioka T, Kumanishi T. Ethanol opens G-protein-activated inwardly rectifying K+ channels. Nat Neurosci. 1999;2:1091–1097.
Walter H, Messing RO. Regulation of neuronal voltage-gated calcium channels by ethanol. Neurochem Int. 1999;35:95–101.
Wei W, Faria LC, Mody I. Low ethanol concentrations selectively augment the tonic inhibition mediated by δ subunit-containing GABAA receptors in hippocampal neurons. J Neurosci. 2004;24:8379–8382.
Hanchar HJ, Wallner M, Olsen RW. Alcohol effects on γ-aminobutyric acid type A receptors: are extrasynaptic receptors the answer? Life Sci. 2004;76:1–8.
Nestoros JN. Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex, Science. 1980;209:708–710.
Suzdak PD, Schwartz RD, Skolnick P, Paul SM. Ethanol stimulates γ-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes. Proc Natl Acad Sci U S A. 1986;83:4071–4075.
Sundstrom-Poromaa I, Smith DH, Gong QH, Sabado TN, Li X, Light A, Wiedmann M, Williams K, Smith SS. Hormonally regulated α4β2δ GABAA receptors are a target for alcohol. Nat Neurosci. 2002;5:721–722.
Wallner M, Hanchar HJ, Olsen RW. Ethanol enhances α4β3δ and α6β3δγ-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc Natl Acad Sci U S A. 2003;100:15218–15223.
Pirker S, Schwarzer C, Wieselthaler A, Sieghart W, Sperk G. GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience. 2000;101:815–850.
Mody I. Distinguishing between GABAA receptors responsible for tonic and phasic conductances. Neurochem Res. 2001;26:907–913.
Kullmann DM, Ruiz A, Rusakov DM, Scott R, Semyanov A, Walker MC. Presynaptic, extrasynaptic and axonal GABAA receptors in the CNS: where and why? Prog Biophys Mol Biol. 2005;87:33–46.
Farrant M, Nusser Z. Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors. Nat Rev Neurosci. 2005;6:215–229.
Morrow AL, Montpied P, Lingford-Hughes A, Paul SM. Chronic ethanol and pentobarbital administration in the rat: effects on GABAA receptor function and expression in brain. Alcohol. 1990;7:237–244.
Mhatre MC, Pena G, Sieghart W, Ticku MK. Antibodies specific for GABAA receptor α subunits reveal that chronic alcohol treatment downregulates α-subunit expression in rat brain regions. J Neurochem. 1993;61:1620–1625.
Kang M, Spigelman I, Sapp DW, Olsen RW. Persistent reduction of GABAA receptor-mediated inhibition in rat hippocampus after chronic intermittent ethanol treatment. Brain Res. 1996;709:221–228.
Montpied P, Morrow AL, Karanian JW, Ginns EI, Martin BM, Paul SM. Prolonged ethanol inhalation decreases γ-aminobutyric acidA receptor a subunit mRNAs in the rat cerebral cortex. Mol Pharmacol. 1991;39:157–163.
Charlton ME, Sweetnam PM, Fitzgerald LW, Terwilliger RZ, Nestler EJ, Duman RS. Chronic ethanol administration regulates the expression of GABAA receptor α1 and α5 subunits in the ventral tegmental area and hippocampus. J Neurochem. 1997;68:121–127.
Follesa P, Mancuso L, Biggio F, Mostallino MC, Manca A, Mascia MP, Busonero F, Talani G, Sanna E, Biggio G. γ-Hydroxybutyric acid and diazepam antagonize a rapid increase in GABAA receptors α4 subunit mRNA abundance induced by ethanol withdrawal in cerebellar granule cells. Mol Pharmacol. 2003;63:896–907.
Kumar S, Kralic JE, O'Buckley TK, Grobin AC, Morrow AL. Chronic ethanol consumption enhances internalization of α1 subunit-containing GABAA receptors in cerebral cortex. J Neurochem. 2003;86:700–708.
Mahmoudi M, Kang MH, Taillakaratne N, Tobin AJ, Olsen RW. Chronic intermittent ethanol treatment in rats increases GABAA receptor α4-subunit expression: possible relevance to alcohol dependence. J Neurochem. 1997;68:2485–2492.
Smith SS, Gong QH, Hsu FC, Markowitz RS, ffrench-Mullen JM, Li X. GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature. 1998;392:926–930.
Hsu FC, Smith SS. Progesterone withdrawal reduces paired-pulse inhibition in rat hippocampus: dependence on GABAA receptor α4 subunit upregulation. J Neurophysiol. 2003;89:186–198.
N'Gouemo P, Caspary DM, Faingold CL. Decreased GABA effectiveness in the inferior colliculus neurons during ethanol withdrawal in rats' susceptibility to audiogenic seizures. Brain Res. 1996;724:200–204.
Faingold CL, Li Y, Evans MS. Decreased GABA and increased glutamate receptor-mediated activity on inferior colliculus neurons in vitro are associated with susceptibility to ethanol withdrawal seizures. Brain Res. 2000;868:287–295.
Whittington MA, Lambert JD, Little HJ. Increased NMDA receptor and calcium channel activity underlying ethanol withdrawal hyperexcitability. Alcohol Alcohol. 1995;30:105–114.
Perez-Velazquez JL, Valiante TA, Carlen PL. Changes in calcium currents during ethanol withdrawal in a genetic mouse model. Brain Res. 1994;649:305–309.
N'Gouemo P, Morad M. Ethanol withdrawal seizure susceptibility is associated with upregulation of L-and P-type Ca2+ channel currents in inferior colliculus neurons. Neuropharmacology. 2003;45:429–437.
Grant KA, Valverius P, Hudspith M, Tabakoff B. Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol. 1990;176:289–296.
Kalluri HS, Mehta AK, Ticku MK. Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment. Brain Res Mol Brain Res. 1998;58:221–224.
Grant KA, Snell LD, Rogawski MA, Thurkauf A, Tabakoff B. Comparison of the effects of the uncompetitive N-methyl-d-aspartate antagonist (±)-5-aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine (ADCI) with its structural analogs dizocilpine (MK-801) and carbamazepine on ethanol withdrawal seizures. J Pharmacol Exp Ther. 1992;260:1017–1022.
Alldredge BK, Lowenstein DH. Status epilepticus related to alcohol abuse. Epilepsia. 1993;34:1033–1037.
Mayo-Smith MF. Pharmacological management of alcohol withdrawal: a meta-analysis and evidence-based practice guideline. JAMA. 1977;278:144–151.
D'Onofrio G, Rathlev NK, Ulrich AS, Fish SS, Freedland ES. Lorazepam for the prevention of recurrent seizures related to alcohol. N Engl J Med. 1999;340:915–919.
Majumdar SK. Chlormethiazole: current status in the treatment of the acute ethanol withdrawal syndrome. Drug Alcohol Depend. 1990;27:201–207.
Morgan MY. The management of alcohol withdrawal using chlormethiazole. Alcohol Alcohol. 1995;30:771–774.
Mhatre MC, McKenzie SE, Gonzalez LP. Diazepam during prior ethanol withdrawals does not alter seizure susceptibility during a subsequent withdrawal. Pharmacol Biochem Behav. 2001;68:339–346.
Becker HC, Veatch LM. Effects of lorazepam treatment for multiple ethanol withdrawals in mice. Alcohol Clin Exp Res. 2002;26:371–380.
Devaud LL, Fritschy JM, Sieghart W, Morrow AL. Bidirectional alterations of GABAA receptor subunit peptide levels in rat cortex during chronic ethanol consumption and withdrawal. J Neurochem. 1997;69:126–130.
Cagetti E, Liang J, Spigelman I, Olsen RW. Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. Mol Pharmacol. 2003;63:53–64.
Usala M, Thompson SA, Whiting PJ, Wafford KA. Activity of chlormethiazole at human recombinant GABAA and NMDA receptors. Br J Pharmacol. 2003;140:1045–1050.
Green, AR.; Davies, EM.; Little, HJ.; Whittington, MA.; Cross, AJ. Psychopharmacology. Berl: 1990. Action of chlormethiazole in a model of ethanol withdrawal. pp. 239–242.
Alldredge BK, Lowenstein DH, Simon RP. Placebo-controlled trial of intravenous diphenylhydantoin for short-term treatment of alcohol withdrawal seizures. Am J Med. 1989;87:645–648.
Chance JF. Emergency department treatment of alcohol withdrawal seizures with phenytoin. Ann Emerg Med. 1991;20:520–522.
Goldstein DB. Sodium bromide and sodium valproate: effective suppressants of ethanol withdrawal reactions in mice. J Pharmacol Exp Ther. 1979;208:223–227.
Myrick H, Malcolm R, Brady KT. Gabapentin treatment of alcohol withdrawal. Am J Psychiatry. 1998;155:1632.
Bonnet U, Banger M, Leweke FM, Maschke M, Kowalski T, Gastpar M. Treatment of alcohol withdrawal syndrome with gabapentin. Pharmacopsychiatry. 1999;32:107–109.
Bozikas V, Petrikis P, Gamvrula K, Savvidou I, Karavatos A. Treatment of alcohol withdrawal with gabapentin. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:197–199.
Voris J, Smith NL, Rao SM, Thorne DL, Flowers QJ. Gabapentin for the treatment of ethanol withdrawal. Subst Abuse. 2003;24:129–132.
Rustembegovic A, Sofic E, Tahirovic I, Kundurovic Z. A study of gabapentin in the treatment of tonic-clonic seizures of alcohol withdrawal syndrome. Med Arh. 2004;58:5–6.
Johnson BA. An overview of the development of medications including novel anticonvulsants for the treatment of alcohol dependence. Expert Opin Pharmacother. 2004;5:1943–1955.
Watson WP, Robinson E, Little HJ. The novel anticonvulsant, gabapentin, protects against both convulsant and anxiogenic aspects of the ethanol withdrawal syndrome. Neuropharmacology. 1997;36:1369–1375.
Cagetti E, Baicy KJ, Olsen RW. Topiramate attenuates withdrawal signs after chronic intermittent ethanol in rats. Neuroreport. 2004;15:207–210.
Rustembegovic A, Sofic E, Kroyer G. A pilot study of topiramate (Topamax) in the treatment of tonic-clonic seizures of alcohol withdrawal syndromes. Med Arh. 2002;56:211–112.
Ballenger JC, Post RM. Kindling as a model for alcohol withdrawal syndromes. Br J Psychiatry. 1978;133:1–14.
Duka T, Gentry J, Malcolm R, Ripley TL, Borlikova G, Stephens DN, Veatch LM, Becker HC, Crews FT. Consequences of multiple withdrawals from alcohol. Alcohol Clin Exp Res. 2004;28:233–246.
Becker HC, Hale RL. Repeated episodes of ethanol withdrawal potentiate the severity of subsequent withdrawal seizures: an animal model of alcohol withdrawal kindling. Alcohol Clin Exp Res. 1993;17:94–98.
Becker, HC.; Veatch, LM.; Diaz-Granados, JL. Psychopharmacology. Berl: 1998. Repeated ethanol withdrawal experience selectively alters sensitivity to different chemoconvulsant drugs in mice. pp. 145–153.
McCown TJ, Breese GR. Multiple withdrawals from chronic ethanol “kindles” inferior collicular seizure activity: evidence for kindling of seizures associated with alcoholism. Alcohol Clin Exp Res. 1990;14:394–399.
Gonzalez LP, Veatch LM, Ticku MK, Becker HC. Alcohol withdrawal kindling: mechanisms and implications for treatment. Alcohol Clin Exp Res. 2001;25(5 suppl ISBRA):197S–201S.
Ulrichsen, J.; Bech, B.; Allerup, P.; Hemmingsen, R. Psychopharmacology. Vol. 121. Berl: 1995. Diazepam prevents progression of kindled alcohol withdrawal behaviour. pp. 451–460.
Löscher, W.; Rogawski, MA. Epilepsy. In: Lodge D, Danysz W, Parsons CG. , editors. Ionotropic Glutamate Receptors as Therapeutic Targets. Johnson City, TN: FP Graham Publishing; 2002. pp. 91–132.
Little HJ, Dolin SJ, Halsey MJ. Calcium channel antagonists decrease the ethanol withdrawal syndrome. Life Sci. 1986;39:2059–2065.
Crabbe JC. Antagonism of ethanol withdrawal convulsions in withdrawal seizure prone mice by diazepam and abecarnil. Eur J Pharmacol. 1992;221:85–90.
Chu NS. Prevention of alcohol withdrawal seizures with phenytoin in rats. Epilepsia. 1981;22:179–184.
Gessner PK. Failure of diphenylhydantoin to prevent alcohol withdrawal convulsions in mice. Eur J Pharmacol. 1974;27:120–129.
Chu NS. Carbamazepine: prevention of alcohol withdrawal seizures. Neurology. 1979;29:1397–1401.
Morrisett RA, Rezvani AH, Overstreet D, Janowsky DS, Wilson WA, Swartzwelder HS. MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur J Pharmacol. 1990;176:103–105.

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