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To investigate a possible new method based on biophysical principles (scrambler therapy) …

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- Untreatable Pain Resulting from Abdominal Cancer: New Hope from Biophysics?

The preliminary results obtained using scrambler therapy are extremely encouraging, both in terms of enhanced pain control after each treatment session and in view of the possible maintenance of effectiveness over time. In the latter case, in agreement with theoretical predictions, a gradual reduction is found in baseline VAS as well as unchanged effectiveness until death results. This can be verified both by analyzing the VAS trend and by processing the differences in PID data. However, one of the aims of the treatment was precisely the reduction of these differences to a minimum by raising the pain threshold. From our data it can actually be seen how the VAS values observed before each treatment session decrease, unlike the trend normally observed in terminal patients [13, 14, 15]. Finally, all patients responded fully to the protocol and none reported undesirable side effects. Compliance was excellent.

The following conclusions may be drawn from these preliminary results:

  • scrambler therapy produced a statistically significant pain control response;

  • the absence of the pain control response was increasingly prolonged for many hours after the end of the session as the number of treatment sessions increased, indicating a favorable remodelling of the pain system;

  • no undesirable side effects were reported;

  • all the patients displayed excellent compliance with the treatment;

  • the support of painkillers rapidly proved unnecessary in 9 patients out of 11 and was reduced to very low levels in the remaining two.

This extremely positive outcome suggests performing more extensive trials of scrambler therapy in order to obtain further knowledge. In view of the completeness and the extent of the results, it may reasonably be assumed to be a very productive approach and thus in the near future it will be possible to treat pancreatic cancer pain easily and without side effects. The intensity and difficult management of this pain has always been considered a focal point of the disease and significant efforts should be made to improve the patient's quality of life, which often amounts to prolonging the life itself.

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