Tissue engineering and regenerative medicine is an exiting interdisciplinary field, which applies to the principles of engineering and biology to the development of viable substitutes that restore the function of damaged tissues and organs. Until now the efforts of tissue engineering science have provided new knowledge that have deepen our understanding of the phenotype and behavior of the skeletal muscle cells. This knowledge may in turn enable promising advances in musculoskeletal tissue engineering. Growing new tissues (neoorganogenesis) is a complex process that requires the teamwork of developmental and cellulare molecular biologists, engineers, material scientistes, and physicians. As the techniques of tissue engineering become more sophisticated, the usefulness of these methods for supporting the possibilities of reconstructive surgery will hopefully become reality.