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Potential Molecular Therapy for Certain Childhood Cancers

According to incomplete statistics, every year in American, over 700 children are newly diagnosed with neuroblastoma, 500 with Wilms’ tumor and 100 with hepatoblastoma, which are all childhood cancers and hepatoblastoma even accounts for 80% of all liver tumors in children. Scientists all over the world had tried a multitude of ways to tackle with those childhood cancers, aiming to find a way which will not restore to chemotherapy.


Fortunately, the hope seems to come. These days, scientists have found that a gene called Lin28 contributes a lot to the development of those cancers.  They found that Lin28 is normally turned on in fetal but not adult tissues---which aroused a hypothesis that blocking the development of Lin28 in children might help decrease the cancer’s growth.


To verify this assumption, those scientists made a test on mice. By increasing the Lin28 significantly and either deleting it, they found that Lin28b can activate the metabolic pathways that provide the building blocks of growth for certain cancers.


However, whether this method would work the same in human, it’s still an unsolved article.  More researches are needed to figure out if genes related to Lin28 have effect on cancer.



This is written by Caroline from Creative Biomart, a world leading Biotech Company.





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