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- Neurobiological Mechanisms of Social Anxiety Disorder

  1. Gorman JM, Kent JM, Sullivan GM, Coplan JD: Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 2000; 157:493-505
  2. Shively CA: Social subordination stress, behavior, and central monoaminergic function in female cynomolgus monkeys. Biol Psychiatry 1998; 44:882-891
  3. Botchin MB, Kaplan JR, Manuck SB, Mann JJ: Low versus high prolactin responders to fenfluramine challenge: marker of behavioral differences in adult male cynomolgus macaques. Neuropsychopharmacology 1993; 9:93-99
  4. Grant KA, Shively CA, Nader MA, Ehrenkaufer RL, Line SW, Morton TE, Gage HD, Mach RH: Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography. Synapse 1998; 29:80-83
  5. Schneier FR, Liebowitz MR, Abi-Dargham A, Zea-Ponce Y, Lin S-H, Laruelle M: Low dopamine D2 receptor binding potential in social phobia. Am J Psychiatry 2000; 157:457-459
  6. Sapolsky RM, Alberts SC, Altmann J: Hypercortisolism associated with social subordinance or social isolation among wild baboons. Arch Gen Psychiatry 1997; 54:1137-1143
  7. Sapolsky RM, Spencer EM: Insulin-like growth factor I is suppressed in socially subordinate male baboons. Am J Physiol 1997; 273(4, part 2):R1346-R1351
  8. Stabler B, Tancer ME, Ranc J, Underwood LE: Evidence for social phobia and other psychiatric disorders in adults who were growth hormone deficient during childhood. Anxiety 1996; 2:86-89
  9. Uhde TW, Tancer ME, Gelernter CS, Vitonne BJ: Normal urinary free cortisol and postdexamethasone cortisol in social phobia: comparison to normal volunteers. J Affect Disord 1994; 30:155-161
  10. Tancer ME, Mailman RB, Stein MB, Mason GA, Carson SW, Golden RN: Neuroendocrine responsivity to monoaminergic system probes in generalized social phobia. Anxiety 1994-1995; 1:216-223
  11. Raleigh MJ, McGuire MT, Brammer GL, Yuwiler A: Social and environmental influences on blood serotonin concentrations in monkeys. Arch Gen Psychol 1984; 41:405-410
  12. Rosenblum LA, Paully GS: The effects of varying environmental demands on maternal and infant behavior. Child Dev 1984; 55:305-314
  13. Andrews MW, Rosenblum LA: Dominance and social competence in differentially reared bonnet macaques, in Primatology Today: XIIIth Congress of the International Primatological Society. Edited by Ehara A. Amsterdam, Elsevier, 1991, pp 347-350
  14. Coplan JD, Andrews MW, Rosenblum LA, Owens MJ, Gorman JM, Nemeroff CB: Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci USA 1996; 93:1619-1623
  15. Coplan JD, Trost R, Owens MJ, Cooper T, Gorman JM, Nemeroff CB, Rosenblum LA: Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions. Arch Gen Psychiatry 1998; 55:473-477
  16. Coplan JD, Smith ELP, Trost RC, Scharf BA, Altemus M, Bjornson L, Owens MJ, Gorman JM, Nemeroff CB, Rosenblum LA: Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations. Psychiatry Res 2000; 95:3-102
  17. Rosenblum LA, Coplan JD, Friedman S, Gorman JM, Andrews MW: Adverse early experiences affect noradrenergic and serotonergic functioning in adult primates. Biol Psychiatry 1994; 35:221-227
  18. Kagan J, Reznick JS, Snidman N: The physiology and psychology of behavioral inhibition. Child Dev 1987; 58:1459-1473
  19. Yehuda R: Psychoneuroendocrinology of post-traumatic stress disorder. Psychiatr Clin North Am 1998; 21:359-379
  20. Southwick S, Krystal J, Morgan C, Johnson D, Nagy L, Nicolaou A, Heninger G, Charney D: Abnormal noradrenergic function in posttraumatic stress disorder. Arch Gen Psychiatry 1993; 50:266-274
  21. Smalley SL, McCracken J, Tanguay P: Autism, affective disorders, and social phobia. Am J Med Genet 1995; 60:19-26
  22. Piven J, Palmer P: Psychiatric disorder and broad autism phenotype: evidence from a family study of multiple-incidence autism families. Am J Psychiatry 1999; 156:557-563
  23. Raleigh MJ, Brammer GL, McGuire MT: Male dominance, serotonergic systems, and the behavioral and physiological effects of drugs in vervet monkeys (Cercopithecus aethiops sabaeus). Prog Clin Biol Res 1983; 131:185-197
  24. Mehlman PT, Higley JD, Faucher I, Lilly AA, Taub DM, Vickers J, Suomi SJ, Linnoila M: Correlation of CSF 5-HIAA concentration with sociality and the timing of emigration in free-ranging primates. Am J Psychiatry 1995; 152:907-913
  25. Schino G, Troisi A: Opiate receptor blockade in juvenile macaques: effect on affiliative interactions with their mothers and group companions. Brain Res 1992; 576:125-130
  26. Kalin NH, Shelton SE, Lynn DE: Opiate systems in mother and infant primates coordinate intimate contact during reunion. Psychoneuroendocrinology 1995; 20:735-742
  27. Uvnas-Moberg K: Oxytocin may mediate the benefits of positive social interaction and emotions. Psychoneuroendocrinology 1998; 23:819-835
  28. Grenyer BF, Williams G, Swift W, Neill O: The prevalence of social-evaluative anxiety in opioid users seeking treatment. Int J Addict 1992; 27:665-673
  29. Insel TR, Winslow JT: The neurobiology of social attachment, in Neurobiology of Mental Illness. Edited by Charney DS, Nestler EJ, Bunney BS. New York, Oxford University Press, 1999, pp 880-890
  30. Winslow JT, Insel TR: Social status in pairs of squirrel monkeys determines the behavioral response to central oxytocin administration. J Neurosci 1991; 11:2032-2038
  31. Stein MB: Neurobiological perspectives on social phobia: from affiliation to zoology. Biol Psychiatry 1998; 44:1277-1285
  32. Lorberbaum JP, Newman JD, Dubno JR, Horwitz AR, Nahas Z, Teneback CC, Bloomer CW, Bohning DE, Vincent D, Johnson MR, Emmanuel N, Brawman-Mintzer O, Book SW, Lydiard RB, Ballenger JC, George MS: Feasibility of using fMRI to study mothers responding to infant cries. Depress Anxiety 1999; 10:99-104
  33. Gould E, Tanapat P: Stress and hippocampal neurogenesis. Biol Psychiatry 1999; 46:1472-1479
  34. Gould E, McEwen BS, Tanapat P, Galea LAM, Fuchs E: Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997; 17:2492-2498
  35. Von Holst D: Social stress in the tree-shrew: its causes and physiological and ethological consequences, in Prosimian Biology. Edited by Martin RD, Doyle GA, Watlker AC. Philadelphia, University of Pittsburgh, 1972, pp 389-411
  36. Gould E, Tanapat P, McEwan BS, Flugge G, Fuchs E: Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA 1998; 95:3168-3171
  37. Gould E, Reeves AJ, Fallah M, Tanapat P, Fuchs E: Hippocampal neurogenesis in adult old world primates. Proc Natl Acad Sci USA 1999; 96:5263-5267
  38. Moghaddam B, Bolinao M, Stein-Behrens B, Sapolsky R: Glucocorticoids mediate the stress induced extracellular accumulation in the hippocampus. J Neurochem 1994; 63:596-602
  39. Stewart J, Kolb B: The effects of neonatal gonadectomy and prenatal stress on cortical thickness and asymmetry in rats. Behav Neural Biol 1988; 49:344-360
  40. Schoups AA, Elliott RC, Friedman WJ, Black IB: NGF and BDNF are differentially modulated by visual experience in the developing geniculocortical pathway. Dev Brain Res 1995; 86:326-334
  41. Nibuya M, Nestler EJ, Duman RS: Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. J Neurosci 1996; 16:2365-2372
  42. Duman RS, Heninger GR, Nestler EJ: A molecular and cellular theory of depression. Arch Gen Psychiatry 1997; 54:597-606
  43. Pine DS, Cohen P, Gurley D, Brook JS, Ma Y: The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry 1998; 55:56-64
  44. Rosen JB, Schulkin J: From normal fear to pathological anxiety. Psychol Rev 1998; 105:325-350
  45. Mick MA, Telch MJ: Social anxiety and history of behavioral inhibition in young adults. J Anxiety Disord 1998; 12:1-20
  46. Schwartz CE, Snidman N, Kagan J: Adolescent social anxiety as an outcome of inhibited temperament in childhood. J Am Acad Child Adolesc Psychiatry 1999; 38:1008-1015
  47. Kagan J: Temperament and the reactions to unfamiliarity. Child Dev 1997; 68:139-143
  48. Hirshfeld DR, Rosenbaum JF, Biederman J, Bolduc EA, Faraone SV, Snidman N, Reznick JS, Kagan J: Stable behavioral inhibition and its association with anxiety disorder. J Am Acad Child Adolesc Psychiatry 1992; 31:103-111
  49. Fyer AJ, Mannuzza S, Chapman TF, Martin LY, Klein DF: Specificity in familial aggregation of phobic disorders. Arch Gen Psychiatry 1995; 52:564-573
  50. Kerr M, Tremblay RE, Pagani L, Vitaro F: Boys’ behavioral inhibition and the risk of later delinquency. Arch Gen Psychiatry 1997; 54:809-816
  51. Calkins S, Fox N, Marshall T: Behavioral and physiological antecedents of inhibited and uninhibited behavior. Child Dev 1996; 67:523-540
  52. Davidson R: Asymmetric brain function, affective style, and psychopathology: the role of early experience and plasticity. Dev Psychopathol 1994; 6:741-758
  53. Kalin NH, Larson C, Shelton SE, Davidson RJ: Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys. Behav Neurosci 1998; 112:286-292
  54. Davidson R: Emotion and affective style: hemispheric substrates. Psychol Sci 1992; 3:39-43
  55. Davidson RJ, Marshall JR, Tomarken AJ, Henriques JB: While a phobic waits: regional brain electrical and autonomic activity in social phobics during anticipation of public speaking. Biol Psychiatry 2000; 47:85-95
  56. Kalin NH, Shelton SE, Davidson RJ: Cerebrospinal fluid corticotropin-releasing hormone levels are elevated in monkeys with patterns of brain activity associated with fearful temperament. Biol Psychiatry 2000; 47:579-585
  57. Rauch SL, Savage CR, Alpert NM, Fischman AJ, Jenike MA: The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation. Biol Psychiatry 1997; 42:446-452
  58. Fyer AJ, Mannuzza S, Chapman TF, Liebowitz MR, Klein DF: A direct interview family study of social phobia. Arch Gen Psychiatry 1993; 50:286-293
  59. Mannuzza S, Schneier FR, Chapman TF, Liebowitz MR, Klein DR, Fyer AJ: Generalized social phobia: reliability and validity. Arch Gen Psychiatry 1995; 52:230-237
  60. Stein MB, Chartier MJ, Hazen AL, Kozak MV, Tancer ME, Lander S, Furer P, Chubaty D, Walker JR: A direct-interview family study of generalized social phobia. Am J Psychiatry 1998; 155:90-97
  61. Mancini C, van Ameringen M, Szatmari P, Fugere C, Boyle M: A high-risk pilot study of the children of adults with social phobia. J Am Acad Child Adolesc Psychiatry 1996; 35:1511-1517
  62. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ: The genetic epidemiology of phobias in women: the interrelationship of agoraphobia, social phobia, situational phobia, and simple phobia. Arch Gen Psychiatry 1992; 49:273-281
  63. Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA, Haghighi F, de Jesus GM, Rassnick H, Preud’homme-Rivelli X, Austin T, Cunjak J, Mick S, Fine LD, Woodley KA, Das K, Maier W, Adams PB, Freimer NB, Klein DF, Gilliam TC: Results of a genome-wide genetic screen for panic disorder. Am J Med Genet 1998; 81:139-147
  64. Hanna GL, Himle JA, Curtis GC, Koram DQ, VanderWeele J, Leventhal BL, Cook EH Jr: Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder. Neuropsychopharmacology 1998; 18:102-11
  65. Lesch KP, Dietmar B, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274:1527-1531
  66. Crowe RR: Molecular genetics of anxiety disorders, in Neurobiology of Mental Illness. Edited by Charney DS, Nestler EJ, Bunney BS. New York, Oxford University Press, 1999, pp 451-462
  67. Hollander E, Kwon J, Weiller F, Cohen L, Stein DJ, DeCaria C, Liebowitz M, Simeon D. Serotonergic function in social phobia: comparison to normal control and obsessive-compulsive disorder subjects. Psychiatry Res 1998; 79:213-217
  68. Johnson MR, Lydiard RB, Zealberg JJ, Fossey MD, Ballenger JC: Plasma and CSF levels in panic patients with comorbid social phobia. Biol Psychiatry 1994; 36:426-427
  69. Stein MB, Heuser IJ, Juncos JL, Uhde TW: Anxiety disorders in patients with Parkinson’s disease. Am J Psychiatry 1990; 147:217-220
  70. Mikkelsen EJ, Detlor J, Cohen DJ: School avoidance and social phobia triggered by haloperidol in patients with Tourette’s disorder. Am J Psychiatry 1981; 138:1572-1576
  71. Liebowitz MR, Schneier F, Campeas R, Hollander E, Hatterer J, Fyer A, Gorman J, Papp L, Davies S, Gully R: Phenelzine vs atenolol in social phobia: a placebo-controlled comparison. Arch Gen Psychiatry 1992; 49:290-300
  72. Simpson HB, Schneier F, Campeas R, Marshall RD, Fallon BA, Davies S, Klein DF, Liebowitz MR: Imipramine in the treatment of social phobia. J Clin Psychopharmacol 1998; 18:132-135
  73. McCann UD, Slate SO, Geraci M, Roscow-Terrill D, Uhde TW: A comparison of the effects of intravenous pentagastrin on patients with social phobia, panic disorder and healthy controls. Neuropsychopharmacology 1997; 16:229-237
  74. Papp LA, Klein DF, Martinez J, Schneier F, Cole R, Liebowitz MR, Hollander E, Fyer AJ, Jordan F, Gorman JM: Diagnostic and substance specificity of carbon-dioxide-induced panic. Am J Psychiatry 1993; 150:250-257
  75. Pine DS, Klein RG, Coplan JD, Papp LA, Hoven CW, Martinez J, Kovalenko P, Mandell DJ, Moreau D, Klein DF, Gorman JM: Differential carbon dioxide sensitivity in childhood anxiety disorders and nonill comparison group. Arch Gen Psychiatry 2000; 57:960-967
  76. Pine DS, Cohen P, Gurley D, Brook JS, Ma Y: The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry 1998; 55:56-64
  77. Stein MB, Tancer ME, Uhde TW: Physiologic and plasma norepinephrine responses to orthostasis in patients with panic disorder and social phobia. Arch Gen Psychiatry 1992; 49:311-317
  78. Stein MB, Asmundson GJG, Chartier M: Autonomic responsivity in generalized social phobia. J Affect Disord 1994; 31:211-221
  79. Potts NL, Book S, Davidson JR: The neurobiology of social phobia. Int Clin Psychopharmacol 1996; 11(suppl 3):43-48
  80. Papp LA, Gorman JM, Liebowitz MR, Fyer AJ, Cohen B, Klein DF: Epinephrine infusions in patients with social phobia. Am J Psychiatry 1988; 145:733-736
  81. Tancer ME, Stein MB, Uhde TW: Growth hormone response to intravenous clonidine in social phobia: comparison to patients with panic disorder and healthy volunteers. Biol Psychiatry 1993; 34:591-595
  82. Tiihonen J, Kuikka J, Bergstrom K, Lepola U, Koponen H, Leinonen E: Dopamine reuptake site densities in patients with social phobia. Am J Psychiatry 1997; 154:239-242
  83. Laruelle M: Imaging synaptic neurotransmission with in vivo binding competition techniques: a critical review. J Cereb Blood Flow Metab 2000; 20:423-451
  84. Davidson JR, Krishnan KR, Charles HC, Boyko O, Potts NL, Ford SM, Patterson L: Magnetic resonance spectroscopy in social phobia: preliminary findings. J Clin Psychiatry 1993; 54(Dec suppl):19-25
  85. Tupler LA, Davidson JRT, Smith RD, Lazeyras F, Charles HC, Krishnan KRR: A repeat proton magnetic resonance spectroscopy study in social phobia. Biol Psychiatry 1997; 42:419-424
  86. Potts NLS, Davidson JRT, Krishnan KR, Doraiswamy PM: Magnetic resonance imaging in social phobia. Psychiatry Res 1994; 52:35-42
  87. Stein MB, Leslie WD: A brain single photon-emission computed tomography (SPECT) study of generalized social phobia. Biol Psychiatry 1996; 39:825-828
  88. Bell CJ, Malizia AL, Nutt DJ: The neurobiology of social phobia. Eur Neuropsychopharmacol 1998; 8:311-313
  89. Birbaumer N, Grodd W, Diedrich O, Klose U, Erb M, Lotze M, Schneider F, Weiss U, Flor H: fMRI reveals amygdala activation to human faces in social phobics. Neuroreport 1998; 9:1223-1226
  90. Hwang DR, Kegeles LS, Laruelle M: (-)-N-[(11)C]propyl-norapomorphine: a positron-labeled dopamine agonist for PET imaging of D(2) receptors. Nucl Med Biol 2000; 27:533-539
  91. Gurley D, Cohen P, Pine DS, Brook J: The comorbidity of anxiety disorders and depression in a large community sample of youth. J Affect Disord 1996; 39:191-200
  92. Horwath E, Wolk SI, Goldstein RB, Wickramaratne P, Sobin C, Adams P, Lish JD, Weissman MM: Is the comorbidity between social phobia and panic disorder due to familial cotransmission or other factors? Arch Gen Psychiatry 1995; 52:574-582
  93. Davis M: Neurobiology of fear responses: the role of the amygdala. Neuropsychopharmacology 1997; 9:382-402
  94. LeDoux J: Fear and the brain: where have we been, and where are we going? Biol Psychiatry 1998; 44:1229-1238
  95. Rosenberg DR, MacMaster FP, Keshavan MS, Fitzgerald KD, Stewart CM, Moore GJ: Decrease in caudate glutamatergic concentrations in pediatric obsessive compulsive disorder patients taking paroxetine. J Am Acad Child Adolesc Psychiatry 2000; 39:1096-1103

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