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A necessary component of Wnt signaling occurs in a subcellular compartment distinct …

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- A critical role for endocytosis in Wnt signaling

Taken together with our results, these data indicate that clathrin-mediated endocytosis may serve two purposes: promotion of Wnt signaling in an endosome, followed by ligand degradation and receptor down-regulation in the lysosomes. The critical balance between an endosomal localization conducive for productive Wnt signaling and lysosomal trafficking for attenuation of the signal may involve an explicit intracellular sorting step. Nevertheless, in the context of previous work on the internalization of Wg [5] and Wnt-5A [6], our study delineates a previously unappreciated role for endocytosis in Wnt signal transduction.

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