such as "Introduction", "Conclusion"..etc
The physiological functions of AQP9 are uncertain. During prolonged fasting, glycerol released from adipocytes via AQP7 may be taken up by the liver via AQP9 for gluconeogenesis. Urea, a byproduct of amino acid deamination, and β-hydroxybutyrate, an alternative fuel, may be released from liver via AQP9. An elegant series of recent studies of adipocyte AQP7 and liver AQP9 mRNAs and promoters suggested that the genes are coordinately regulated during fasting and type 1 diabetes mellitus (9), but this has not been confirmed with studies of the AQP7 and AQP9 proteins.
We undertook studies to define the permeation of proteoliposomes reconstituted with purified rat AQP9 protein and to provide evidence that expression of AQP9 protein is altered in rats during fasting and insulin deficiency. Our studies indicate that AQP9 facilitates hepatocyte glycerol influx and urea efflux, establishing a greater functional repertoire for AQP9 as a solute channel with minor water transport capacity.
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