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<h2> <strong>Fibroblast heterogeneity: more than skin deep</strong> </h2> <p> <strong>J. Michael Sorrell<sup></sup> and Arnold I. Caplan </strong> </p> <p> Skeletal Research Center, Biology Department, Case Western Reserve University, Cleveland, OH 44106, USA </p> <p> <sup></sup> Author for correspondence (e-mail: <span><a href="mailto:jms30@cwru.edu">jms30@cwru.edu</a></span> ) </p> <p></p> <a title="ABS"></a> <p> <br><strong>Summary</strong> <br> </p> <p> Dermal fibroblasts are a dynamic and diverse population of cells<sup></sup>whose functions in skin in many respects remain unknown. Normal<sup></sup>adult human skin contains at least three distinct subpopulations<sup></sup>of fibroblasts, which occupy unique niches in the dermis. Fibroblasts<sup></sup>from each of these niches exhibit distinctive differences when<sup></sup>cultured separately. Specific differences in fibroblast physiology<sup></sup>are evident in papillary dermal fibroblasts, which reside in<sup></sup>the superficial dermis, and reticular fibroblasts, which reside<sup></sup>in the deep dermis. Both of these subpopulations of fibroblasts<sup></sup>differ from the fibroblasts that are associated with hair follicles.<sup></sup>Fibroblasts engage in fibroblast-epidermal interactions during<sup></sup>hair development and in interfollicular regions of skin. They<sup></sup>also play an important role in cutaneous wound repair and an<sup></sup>ever-increasing role in bioengineering of skin. Bioengineered<sup></sup>skin currently performs important roles in providing (1) a basic<sup></sup>understanding of skin biology, (2) a vehicle for testing topically<sup></sup>applied products and (3) a resource for skin replacement.<sup></sup> </p> <p></p> <p> <strong>Key words:</strong> Skin, Fibroblasts, Skin equivalents </p> <p> <span style="font-size:10pt;color:#000000;font-family:Arial;"></span> </p> <p> <em>Source: Journal of Cell Science 117, 667-675 (2004)</em> </p>
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