such as "Introduction", "Conclusion"..etc
February 2009 — Researchers at The Medical
College of Wisconsin in Milwaukee have linked higher levels of the
hormone aldosterone to high blood pressure and blood vessel disease in
African Americans. Aldosterone is secreted by the adrenal glands and
causes salt retention by the kidneys.
The study appeared in the December 18, 2008, American Journal of Hypertension.
"The prevalence of high blood pressure, or hypertension, in African
Americans is among the highest in the world," says lead researcher
Theodore Kotchen, M.D., professor of medicine and associate dean for
"Previously, we found relatively high aldosterone levels in African
Americans with high blood pressure," he said. "In this study we have
found that aldosterone may not only contribute to high blood pressure
but also to related changes in blood vessel function in the kidneys and
The researchers compared 24-hour blood pressures, heart output,
blood vessel stiffness, kidney blood flow, and aldosterone levels in
224 African Americans with high blood pressure, with those of 217
African Americans with normal blood pressure.
They found that those with high blood pressure had higher levels of
aldosterone. Their heart output was lower, extremity blood vessel
stiffness was greater, kidney blood flow was lower, and kidney
resistance to blood flow was higher than those with normal blood
Most importantly, the blood pressure levels, blood vessel
flexibility, and kidney blood flow in those with high blood pressure
were all directly correlated with their aldosterone levels.
"These observations suggest that aldosterone contributes to high
blood pressure and its related heart, kidney, and blood vessel disease
in African Americans," says Dr. Kotchen.
His research has been continuously funded by the National Institutes
of Health's National Heart, Lung and Blood Institute for over a decade.
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