such as "Introduction", "Conclusion"..etc
February 2008 — Despite millions of dollars
spent on food safety research over the last 10 years, ground beef
recalls due to E. coli O157:H7 were higher in 2007 than in 2006,
according to researchers from Kansas State University and West Texas
A&M University. E. coli O157:H7 has been linked to foodborne
illnesses in humans after consuming contaminated beef and produce.
"We have been studying the effects of a novel vaccine technology to
make beef safer," said Dr. Dan Thomson, an associate professor at
Kansas State University.
Thomson worked with Dr. Guy Loneragan, West Texas A&M
University, and Dr. T.G. Nagaraja, of K-State, to examine the effects
of this vaccine on its ability to decrease E. coli shedding in beef
"We had a decrease in cattle shedding E. coli by 54 percent in our
first field study," Thomson said. "However, we increased the amount of
SRP exposure in the second field study and decreased the rate of cattle
shedding E. coli by 85 percent."
Loneragan said, "This tells us that efficacious interventions that
predictably reduce the burden of E. coli O157 on cattle entering
packing plants are needed. Successful interventions will reduce the
burden of E. coli O157 to a level that is within the capacity of
in-plant interventions to handle. If this can be achieved, then
tremendous progress toward preventing E. coli O157 from ever getting
into ground beef has been made. This vaccine appears to fit this
purpose and has great promise."
Thomson and his colleagues studied Siderophore receptor and porin --
SRP -- technology, which was developed by Epitopix, LLC in Willmar,
"Siderophore receptor and porin proteins are utilized by food borne
pathogens like E. coli to acquire iron," Thomson said. "The SRP vaccine
technology immunizes animals against these mechanisms and does not
allow the bacteria to take up iron. Iron is to bacteria, as oxygen is
to humans. Without iron consumption, the bacteria suffocate and can't
grow or replicate."
"We conducted a challenge study, a natural infection study and two
large pen field studies at commercial feedyards," Thomson said. "All
studies showed positive results of this vaccine, making an impact on
decreasing not only the number of the cattle shedding the bacteria but
also decreasing the concentration of the bacteria being shed."
Super shedder cattle are cattle that shed E. coli in very high
concentrations. "Our natural field study showed that the SRP technology
vaccine reduces the number of super shedder cattle," Thomson said.
The two large pen feeding studies the team conducted utilized 20
pens and more than 1,200 head of cattle, Thomson said. The first study
conducted in 2006 was funded in part by beef and veal producers and
importers through their $1-per-head checkoff and was produced for the
Cattlemen's Beef Board and state beef councils by the National
Cattlemen's Beef Association. The second study was sponsored by
Epitopix, LLC in 2007.
The team's findings will be presented at the 2008 Beef Industry Safety Summit in Dallas March 5.
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