such as "Introduction", "Conclusion"..etc
Researchers at Emory University
in Atlanta, GA, recommend that progesterone (PROG), a
naturally occurring hormone found in both males and females that can protect
damaged cells in the central and peripheral nervous systems, be considered a
viable treatment option for traumatic brain injuries, according to a clinical
perspective published in the January issue of the American Journal of
“Traumatic brain injury (TBI) is an
important clinical problem in the United States and around the
world,” said Donald G. Stein, PhD, lead author of the paper. “TBI has received
more attention recently because of its high incidence among combat casualties
in Iraq and Afghanistan.
Current Department of Defense statistics indicated that as many as 30 percent
of wounded soldiers seen at Walter Reed Army Hospital have suffered a TBI, a
finding that has stimulated government interest in developing a safe and
effective treatment for this complex disorder,” said Stein.
“Growing evidence indicates that
post-injury administration of PROG in a variety of brain damage models can have
beneficial effects, leading to substantial and sustained improvements in brain
functionality. PROG given to both males and females can cross the blood-brain
barrier and reduce edema (swelling) levels after TBI; in different models of
cerebral ischemia (restriction of blood supply), significantly reduce the area
of necrotic cell death and improve behavioral outcomes; and protect neurons
distal to the injury that would normally die,” said Stein.
PROG was recently tested in two
phase 2 clinical trials for traumatic brain injury and will begin a phase 3 NIH
sponsored trial soon.
“Given its relatively high safety
profile, its ease of administration, its low cost and ready availability, PROG
should be considered a viable treatment option — especially because, in brain
injury, so little else is currently available,” said
-- News release courtesy of
American Roentgen Ray
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