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October 16, 2009 — A study by researchers at
the University of California, San Diego School of Medicine reports a
significant breakthrough in explaining gaps in scientists'
understanding of human brain function. The study – which provides a
picture of language processing in the brain with unprecedented clarity
– will be published in the October 16 issue of the journal Science.
"Two central mysteries of human brain function are addressed in this
study: one, the way in which higher cognitive processes such as
language are implemented in the brain and, two, the nature of what is
perhaps the best-known region of the cerebral cortex, called Broca's
area," said first author Ned T. Sahin, PhD, post-doctoral fellow in the
UCSD Department of Radiology and Harvard University Department of
The study demonstrates that a small piece of the brain can compute
three different things at different times – within a quarter of a
second – and shows that Broca's area doesn't just do one thing when
processing language. The discoveries came through the researchers' use
of a rare procedure in which electrodes were placed in the brains of
patients. The technique allowed surgeons to know which small region of
the brain to remove to alleviate their seizures, while sparing the
healthy regions necessary for language. Recordings for research
purposes were then made while the patients were awake and responsive.
The procedure, called Intra-Cranial Electrophysiology (ICE), allowed
the researchers to resolve brain activity related to language with
spatial accuracy down to the millimeter and temporal accuracy down to
This is the first experiment to use ICE to document how the human brain computes grammar and produces words.
Because complex language is unique to humans, it has been difficult
to investigate its neural mechanisms. Brain-imaging methods such as
functional MRI are generally all that are possible to use in humans,
but they blur the activity of thousands or millions of neurons over
long periods of time. Consequently, scientists have been unable to
determine in detail whether the mechanisms used by linguistic or
computational models to produce grammatically correct speech correspond
to the mechanisms that the brain actually uses.
For this study, the researchers recorded activity inside patients'
brains while they repeated words verbatim or produced them in
grammatical forms such as past tense or plural – a task that humans
effortlessly compute every time they utter a sentence. ICE enabled the
authors to look at three components of language processing in real
time, to determine whether related neuronal activities were implemented
serially or in parallel, in local or distributed patterns.
"We showed that distinct linguistic processes are computed within
small regions of Broca's area, separated in time and partially
overlapping in space," said Sahin. Specifically, the researchers found
patterns of neuronal activity indicating lexical, grammatical and
articulatory computations at roughly 200, 320 and 450 milliseconds
after the target word was presented. These patterns were identical
across nouns and verbs and consistent across patients.
"The first evidence that parts of the brain may correspond to parts
of the the mind was the discovery that patients with damage to Broca's
area were unable to talk but could still think. In the 150 years since
this discovery, progress in understanding what precisely Broca's area
contributes to language has been disappointing," said principal
investigator Eric Halgren, PhD, professor in the UCSD Department of
Radiology. "These results suggest that Broca's area actually consists
of several overlapping parts, performing distinct computational steps
in a tightly timed choreography, a dance that may simply have been
undetectable due to the level of resolution of previous methods."
According to Sahin, the results help dispel a commonly taught notion
that Broca's area handles expressive language (speaking) while another
part of the cortex called Wernicke's area handles receptive language
(reading and hearing). This notion is still taught in many text books.
"Our task involved both reading and speaking, and we found that
aspects of word identity, grammar and pronunciation are all computed
within Broca's area. Crucially, information about the identity of a
printed word arrives in Broca's area very quickly after it is seen, in
parallel with its arrival in Wernicke's. It has been clear for some
time that the expressive/receptive model is out of date, and now it is
clearer that Broca's area has several roles, in both expressive and
receptive language," said Sahin.
Additional contributors to the paper included Steven Pinker,
Department of Psychology, Harvard University; Sydney S. Cash,
Department of Neurology, Massachusetts General Hospital, Boston; and
Donald Schomer, Department of Neurology, Beth Israel-Deaconess Medical
Major support for the study came from the National Institute of
Neurological Disorders and Stroke of the NIH, with additional support
from the NIH, the Mental Illness and Neuroscience Discovery Institute
at Harvard University, the Sackler Scholars Programme in Psychobiology
at the Weill Medical College of Cornell University, and the Harvard
Source : University of California - San Diego
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