such as "Introduction", "Conclusion"..etc
in China are reporting discovery of unusual liver proteins, found only in
males, that may help explain the long-standing mystery of why the hepatitis B
virus (HBV) sexually discriminates -- hitting men harder than women. Their
study has been published online in ACS’ Journal
of Proteome Research, a monthly publication.
Shuhan Sun, Fang Wang and colleagues note that chronic hepatitis B seems to
progress and cause liver damage faster in men, with men the main victims of the
virus’s most serious complications -- cirrhosis and liver cancer. Men infected
with HBV also are 6 times more likely than women to develop a chronic form of
the disease. About 400 million people worldwide have chronic hepatitis B,
including a form that is highly infectious and can be transmitted through
blood, saliva, and sexual contact.
In experiments with laboratory mice, the scientists found abnormal forms of
apolipoprotein A-I (Apo A-I), a protein involved in fighting inflammation, in
the livers of infected male mice but not infected females. They then identified
abnormal forms of these Apo A-I proteins in blood of men infected with HBV, but
not in women. In addition to explaining the gender differences, the proteins
may provide important markers for tracking the progression of hepatitis B, the
-- News release courtesy of the
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