such as "Introduction", "Conclusion"..etc
July 13, 2009 — The genomes or
DNA of microbes contain defined DNA patterns called genome signatures.
Such signatures may be used to establish relationships and to search
for DNA from viruses or other organisms in the microbes' genomes.
Foreign DNA in bacteria has often been associated with disease-causing
In his doctorate, Jon Bohlin studied methods for examining the
genome signatures of microbes. Since foreign DNA in the genomes of
bacteria often give the bacteria disease-causing abilities, part of his
work was aimed at developing fast and simple methods for finding
The explosive development in technology for sequencing DNA molecules
has made enormous amounts of genetic information available for
analysis. This has both led to an upheaval in biological research and
simultaneously created a great need for fast and effective methods of
interpreting the steadily increasing amounts of information.
To solve the challenges that these large amounts of information
present, bioinformational research is utilising techniques taken from
statistical, mathematical and information technologies. Most of the
methods that were used in this project were originally established in
the field of theoretical bioinformation. However, because of
insufficient information, it was not previously possible to investigate
the methods properly.
The increasing number of sequenced genomes that has become available
during recent years has made it possible to test the methods'
advantages and disadvantages, possibilities and limitations. This has
given us more reliable information on how different microbes' DNA
composition is influenced by environment and lifestyle.
The methods can also be used to deepen our understanding of the
evolutionary development that follows natural selection at the DNA
level. Such knowledge is absolutely necessary to understand mechanisms
leading to bacteria becoming pathogenic (disease-producing) and
resistant to antibiotics.
This doctorate comprises analyses of the genome signatures of
microbes, and describes how genome signatures vary in the genomes of
both closely-related microbes and among different microbial genomes.
One of the central questions is how environment influences the genome
signatures and if this influence may be may be linked to different
characteristics of the microbes, such as size, DNA composition,
lifestyle and niche.
Cand. scient. Jon Bohlin defended his Ph. D. thesis, entitled
"Genomic signatures in prokaryotic genomes", at the Norwegian School of
Veterinary Science, on June 5, 2009.
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