such as "Introduction", "Conclusion"..etc
June 29, 2009 — Dr. Jennifer C Palmer and
colleagues at the University of Bristol have discovered that endothelin
converting enzyme-2 (ECE-2) may cause the decrease in cerebral blood
flow seen in Alzheimer's disease.
Alzheimer's disease is the most common form of dementia. Aβ peptide,
which accumulates in the brain of Alzheimer's disease patients, is
thought to lead to tightening of the blood vessels and reduction of
cerebral blood flood. ECE-2 may contribute to these symptoms by
converting an inactive precursor to endothelin-1, which constricts
To determine if ECE-2 affects cerebral blood flow in Alzheimer's
disease, Palmer et al examined the expression of ECE-2. They found that
ECE-2 levels were elevated in patients with Alzheimer's disease and
that Aβ could increase ECE-2 expression in vitro. These data indicate
that ECE-2 levels are increased in response to Aβ and may cause the
decrease in cerebral blood flow seen in Alzheimer's disease.
Palmer et al "suggest that [endothelin-1] receptor antagonists,
already licensed for treating other diseases, could be of benefit in
[Alzheimer's disease] therapies."
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