such as "Introduction", "Conclusion"..etc
Csaba Ortutay1 and Mauno Vihinen1,2
1Institute of Medical Technology, FI-33014 University of Tampere, Finland
2Tampere University Hospital, FI-33520 Tampere, Finland
Immunome Research 2008,
4:4doi:10.1186/1745-7580-4-4. Open Access article distributed under the terms of the Creative Commons Attribution License.
Details of the mechanisms and selection pressures that shape the
emergence and development of complex biological systems, such as the
human immune system, are poorly understood. A recent definition of a
reference set of proteins essential for the human immunome, combined
with information about protein interaction networks for these proteins,
facilitates evolutionary study of this biological machinery.
Here, we present a detailed study of the development of the immunome
protein interaction network during eight evolutionary steps from
Bilateria ancestors to human. New nodes show preferential attachment to
high degree proteins. The efficiency of the immunome protein
interaction network increases during the evolutionary steps, whereas
the vulnerability of the network decreases.
Our results shed light on selective forces acting on the emergence
of biological networks. It is likely that the high efficiency and low
vulnerability are intrinsic properties of many biological networks,
which arise from the effects of evolutionary processes yet to be
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