such as "Introduction", "Conclusion"..etc
June 24, 2009) — Why the immune system of a
pregnant woman does not attack her developing fetus is one of most
remarkable features of pregnancy, and several underlying mechanisms
have been described. However, Adrian Erlebacher and colleagues, at the
New York University School of Medicine, New York, have now identified a
new mechanism to explain why the mouse maternal immune system does not
attack the fetuses.
Once an embryo implants into the wall of the uterus, a cellular
structure known as the decidua forms around the embryo and placenta. In
the study, the formation of the decidua was found to prevent immune
sentinel cells known as DCs from leaving the maternal/fetal interface
and traveling to the local lymph nodes to activate an immune response
toward the fetus.
The authors therefore suggest that impaired formation or function of
the human decidua might allow DCs to leave the decidua to initiate an
aggressive immune response toward the fetus, something that might
contribute to poor pregnancy outcomes.
In an accompanying commentary, Bali Pulendran, at Emory Vaccine
Center at Yerkes National Primate Research Center, Atlanta, discusses
how this new research affects current thinking about avoiding immune
surveillance at the maternal/fetal interface.
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