such as "Introduction", "Conclusion"..etc
April 23, 2007 — Autoimmune diseases such as
type I diabetes and rheumatoid arthritis are caused by the immune
system attacking the body's own tissues. Determining the factors that
trigger the immune system to attack is an area of intensive research.
In a new study in the Journal of Clinical Investigation, Raphael
Clynes and colleagues from Columbia University show that autoantibodies
are required to induce disease in a mouse model of autoimmune diabetes
mediated by immune cells known as T cells. When CD8+ T cells that
recognize ovalbumin were transplanted into mice expressing ovalbumin in
the pancreas (the organ targeted by the immune system in type I
diabetes) they caused diabetes only if the mice were also transplanted
with IgG antibodies that recognize ovalbumin.
The antibodies were shown to enable immune cells known as dendritic
cells to take up dying pancreatic cells expressing ovalbumin and
present the ovalbumin to CD8+ T cells (a process known as
cross-presentation) in a form that they could "see". Cross-presentation
required that the dendritic cells express activating IgG1 receptors.
Because ovalbumin-specific antibodies were required for the
activation of disease-causing T cells the authors suggest that
developing approaches to prevent autoantibodies from enabling dendritic
cells to cross-present self antigen to T cells might provide a new
approach to treat autoimmune diseases.
Article: Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance
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