such as "Introduction", "Conclusion"..etc
have used genetic engineering to tame one of the most deadly food
poisoning microbes and turn it into a potential new way of giving
patients medicine and vaccines in pills rather than injections. The
study is in the current issue of ACS’ Molecular Pharmaceutics, a bi-monthly journal.
Colin Pouton and colleagues note that patients by far prefer pills and
capsules to the discomfort and inconvenience of injections. But many
medicines and vaccines cannot be given by mouth because they would be
destroyed by stomach acid without being absorbed into the bloodstream.
One promising approach is to use live bacteria, which can survive those
harsh conditions and pass easily from the GI tract into the blood.
The scientists describe development of a new strain of Listeria monocytogenes,
bacteria that normally cause food poisoning, but which have been
genetically engineered to be harmless. Instead of causing disease, the
new microbes can be loaded with medicine or vaccine, and deliver that
beneficial cargo by “infecting” cells. After entering cells, the
bacteria burst and die, leading to Pouton’s term “suicidal strain” for
the microbes. The researchers demonstrated that engineered bacteria
containing a test protein could successfully penetrate a group of
intestinal cells grown in the lab and deliver the protein inside the
cells while leaving the cells unharmed. The findings suggest that the
approach could potentially work in humans, the researchers say.
-- News release courtesy of American Chemical Society
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