such as "Introduction", "Conclusion"..etc
February 5, 2009 — Scientists from Queen Mary,
University of London have discovered a new part of the mechanism which
allows our bodyclocks to reset themselves on a molecular level.
Circadian clocks regulate the daily fluctuations of many
physiological and behavioural aspects in life, and are synchronised
with our surrounding environment via light or temperature cycles.
Natural changes in the length of the day mean that an animal's
circadian clock often has to reset itself on a molecular level, to
avoid getting out of sync with the changing calendar.
Professor Ralf Stanewsky and his team from Queen Mary's School of
Biological and Chemical Sciences study the circadian clocks of
Drosophila, a type of fruit fly. Writing in the journal Current
Biology, they report that the resetting process is governed by three
factors, called Cryptochrome, Jetlag and Timeless.
The team's findings suggest that the light responses of circadian
clocks are fine tuned on a molecular, by small differences in the
binding affinities of clock proteins.
Professor Stanewsky explains: "A circadian photoreceptor called Cry
is activated by light in the blue spectrum. Once active, Cry then
becomes able to bind to a protein called Jetlag. The Jetlag protein
then helps to destroy another protein called Timeless, which is used to
reset the bodyclock.
"Crucially though, we found that Jetlag also helps to destroy the
original photoreceptor Cry itself. This allows the Timeless protein to
reaccumulate during the next day, making sure that the clock mechanism
continues to tick."
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