such as "Introduction", "Conclusion"..etc
Joshua Lederberg*, Emil C. Gotschlich
PLoS Biol 3(10): e341 doi:10.1371/journal.pbio.0030341. [Open Access]
McCarty, who devoted his life as a physician-scientist to studying
infectious disease organisms, was best known for his part in the
monumental discovery that DNA, rather than protein, constituted the
chemical nature of a gene. Uncovering the molecular secret of the gene
in question—that for the capsular polysaccharide of pneumococcal
bacteria—led the way to studying heredity not only through genetics but
also through chemistry, and initiated the dawn of the age of molecular
biology. McCarty was the youngest and longest surviving member of the
research team responsible for this feat, which also included Oswald T.
Avery and Colin MacLeod; he died on January 2, 2005, from congestive
McCarty was born in 1911 in South Bend, Indiana,
the second of four sons of a branch manager for the Studebaker
Corporation while it was still a firm for horse-drawn carriages. In his
teens, McCarty set himself the goal of becoming a physician-scientist,
and he pursued a successful strategy to prepare for admission to, and
early success in, Johns Hopkins University Medical School. As an
undergraduate at Stanford University, he presciently began his studies
in the nascent field of biochemistry, working with James Murray Luck on
protein turnover in the liver. In 1937, he began his clinical training
in pediatrics at the Harriet Lane Service at Johns Hopkins University.
There McCarty developed a special interest in infectious diseases—in
particular, antibacterial sulfonamide drug treatments that were just
entering medicine—which he subsequently pursued by moving to New York
University to work with William Tillett. A National Research Council
Fellowship in the medical sciences and an opening in Oswald T. Avery's
laboratory spurred his move to Rockefeller University in 1941.
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