such as "Introduction", "Conclusion"..etc
Chemists in Canada have
developed a new approach for producing more effective medical antifreeze fluids
for preserving kidneys, hearts, and other organs donated for transplantation.
These next-generation antifreezes can decrease damage to organs caused by ice
crystals, and thus prolong the time a donated organ will remain viable prior to
transplantation. This could increase the number of available organs for
potential recipients. Their study is scheduled for the current issue of the
Journal of the American Chemical
Society, a weekly publication.
Robert N. Ben and colleagues note
that the growth of ice crystals is a major cause of damage to cells, tissues and
organs during cryopreservation, which leaves them unusable for transplantation.
To address this challenge, the researchers developed synthetic antifreeze
materials, called C-linked antifreeze glycoprotein analogues (C-AFGP). These
proteins contain a sugar coating and have custom-tailored antifreeze activity.
the scientists describe the development of “hydration index” that can be used to
more reliably predict how prospective antifreeze materials will behave. Their
index provides a clearer picture of how water molecules interact with the sugar
component (as well as native AFGP) and affect their chemical behavior. This is a
key to understanding their ability to resist the formation of ice crystals when
-- An American Chemical Society (ACS) News Release on December 17, 2008.
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