such as "Introduction", "Conclusion"..etc
Chili peppers can do more than just make you feel hot; the active
chemical in peppers can directly induce thermogenesis, the process by
which cells convert energy into heat, according to a new study.
Capsaicin is the chemical in chili peppers that contributes to their
spiciness; CPS stimulates a receptor found in sensory neurons, creating
the heat sensation and subsequent reactions like redness and sweating.
Now, Yasser Mahmoud has found that capsaicin can create "heat" in a
more direct manner by altering the activity of a muscle protein called
SERCA. Normally, muscle contraction initiates following the release of
a wave of calcium ions from a compartment called the sarcoplasmic
reticulum (SR); SERCA then actively pumps the calcium back into the SR
(using ATP energy), causing muscle relaxation and renewing the cycle.
Capsaicin, however, can attach to SERCA and "uncouple" this pumping
activity; that is, the protein still burns ATP energy but doesn't use
it to pump calcium. Instead, all the ATP energy is given off as heat.
This uncoupling, known as thermogenesis, is one important method of
staying warm and is most often seen in hibernating animals.
Mahmoud notes that capsaicin is the first natural compound known to augment the thermogenesis process .
These findings further explain how capsaicin intake can increase
metabolism and body temperature. And although these studies required
relatively high amounts of capsaicin (probably more than someone could
eat), the structure of capsaicin could be used as a model to design
more potent compounds that might have clinical use such as treating
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