such as "Introduction", "Conclusion"..etc
Bruce A. Sullenger
Departments of Surgery and Genetics, Duke University Medical Center, Durham, North Carolina, USA
correspondence to: Bruce A. Sullenger, Box 2601, Duke University
Medical Center, Durham, North Carolina 27710, USA. Phone: (919)
684-6375; Fax: (919) 684-6492; E-mail: email@example.com.
J. Clin. Invest.
Attempts to employ nucleic acids
in gene therapy have become commonplace in recent years, but efficient
gene transfer methods have proved unexpectedly difficult to devise, and
safety concerns linger. At the same time, however, the study of nucleic
acids has revealed remarkable properties of DNA and RNA molecules that
could make them attractive therapeutic agents, independent of their
well-known ability to encode biologically active proteins. Now would
seem to be a good time to consider alternative uses of nucleic acids
that do not rely on virus-based vectors or even on gene transfer.
Accordingly, the strategies
explored in this Perspective series exploit a number of different
facets of RNA and DNA biochemistry. Certain nucleic acid molecules can
bind to and inhibit the function of target proteins, while others
provide a source of tumor antigens, and still others can perform
catalysis. Recently, therapies that employ nucleic acids in some of
these novel ways have passed the stage of in vitro and animal tests and
have begun to be evaluated in clinical trials for treating a variety of
disorders. This Perspective series offers an update on the progress in
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