such as "Introduction", "Conclusion"..etc
The enzyme TPPII may contribute to obesity by stimulating the formation
of fat cells, suggests a study in EMBO reports this week. The enzyme,
TPPII, has previously been linked to making people feel hungry, but
Jonathan Graff and colleagues now show that it may be even more deeply
involved in causing obesity.
The team found that TPPII actually
stimulated the formation of fat cells in worms and mammalian cells and
that by reducing it, fat stores decreased. Mice with lower levels of
TPPII were thinner than their wild type littermates, although their
food intake was comparable.
The authors hope that TPPII could be exploited as a drug target to help
fight increasing levels of obesity; inhibiting the enzyme would both
increase feelings of fullness after eating and decrease build up of fat
Around 40 million Americans are obese and the UK
Government predicts that 12 million adults in the UK will be obese by
2010 if nothing is done. Obesity is responsible for 70% of
cardiovascular diseases and 80% of type II diabetes and represents a
serious health risk and financial drain. European Molecular Biology Organization. October 2007.
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