such as "Introduction", "Conclusion"..etc
A chemical called candidaspongiolide (CAN) inhibits protein synthesis
but also kills cancer cells by triggering caspase 12-dependent
programmed cell death, according to an article in the Aug. 26 online
issue of the Journal of the National Cancer Institute.
Previous reports showed that CAN preferentially killed glioma and
melanoma cells in vitro, but its mechanism of action was unknown.
In the current study, Giovanni Melillo, M.D., of the National Cancer
Institute in Frederick, Md., and colleagues used molecular and cell
assays to uncover the mechanism by which CAN kills cancer cells in
CAN halts protein synthesis in both normal and cancer cells but does
not kill normal cells at dosages that trigger cell death in the
malignant cells. CAN induces cell death by activating caspase 12 by an
unusual biochemical pathway.
The investigators conclude that further tests with CAN are warranted in vitro and in animal models.
Journal of the National Cancer Institute. August 2008.
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