such as "Introduction", "Conclusion"..etc
could improve the success rate of in vitro fertilization using a "lab
on a chip" to study embryos. Above is a mouse embryo at the fifth day
of development cultured in a 1 microliter droplet. Credit: Mark Johnson and Amanda Pennington
In a finding that could boost the success rate of in vitro fertilization (IVF),
researchers report development of a tiny “lab on a chip” to evaluate the fitness
of embryos harvested for transfer. A report on the approach — which researchers
describe as faster, easier, and more reliable than conventional embryo selection
methods — is scheduled for the Sept. 1 issue of ACS’ Analytical Chemistry, a semi-monthly
In the new study, Todd Thorsen and colleagues note that the
current method for evaluating an embryo's fitness for IVF involves microscopic
examination of the embryo’s physical characteristics, such as cell shape, which
is time-consuming and unreliable. Almost 130,000 women undergo IVF procedures
each year in the U.S. alone, but the procedure has
only a 30 percent success rate. To boost IVF success, doctors often transfer
more than one embryo to the uterus, which can lead to multiple births and
increases the pregnancy risks to mother and child. A better, more targeted
method of embryo selection is needed, the researchers say.
scientists describe development of a so-called microfluidic chip, about the size
of a quarter. It is intended to automatically analyze the health of embryos
intended for transplant by measuring how the embryo alters key nutrients in the
tissue culture medium used to nurture embryos. In laboratory studies, the
researchers collected fluids surrounding 10 mouse embryos and added the fluids
to the computer-controlled chip for analysis. They showed that the device could
quickly (in minutes instead of hours) and accurately measure the nutrient
content of the sample fluids. Besides improving the quality of embryos chosen
for IVF, the system could ultimately cut costs associated with the procedure,
the scientists say.
News release from American Chemical Society (ACS) on August 27, 2008.
Enter the code exactly as it appears. All letters are case insensitive.