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<p> <strong>Christopher I Petkov, Christoph Kayser, Mark Augath and Nikos K Logothetis</strong> </p> <p> <em>Max Planck Institute for Biological Cybernetics, Tübingen, Germany </em> </p> <div> <em>Robert Zatorre, <span>Academic Editor</span></em> </div> <div> <em>McGill University, Canada</em> </div> <p> </p> <div> <strong>Abstract: </strong>Anatomical studies propose that the primate auditory cortex contains more fields than have actually been functionally confirmed or described. Spatially resolved functional magnetic resonance imaging (fMRI) with carefully designed acoustical stimulation could be ideally suited to extend our understanding of the processing within these fields. However, after numerous experiments in humans, many auditory fields remain poorly characterized. Imaging the macaque monkey is of particular interest as these species have a richer set of anatomical and neurophysiological data to clarify the source of the imaged activity. We functionally mapped the auditory cortex of behaving and of anesthetized macaque monkeys with high resolution fMRI. By optimizing our imaging and stimulation procedures, we obtained robust activity throughout auditory cortex using tonal and band-passed noise sounds. Then, by varying the frequency content of the sounds, spatially specific activity patterns were observed over this region. As a result, the activity patterns could be assigned to many auditory cortical fields, including those whose functional properties were previously undescribed. The results provide an extensive functional tessellation of the macaque auditory cortex and suggest that 11 fields contain neurons tuned for the frequency of sounds. This study provides functional support for a model where three fields in primary auditory cortex are surrounded by eight neighboring “belt” fields in non-primary auditory cortex. The findings can now guide neurophysiological recordings in the monkey to expand our understanding of the processing within these fields. Additionally, this work will improve fMRI investigations of the human auditory cortex. </div> <div> </div> <div> <em>Full text available in <span>PLoS Biol. </span><span>2006 July; </span><span>4</span><span>(7)</span><span>: e215.</span></em> </div> <p> </p>
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